The empirical power of rare variant association methods: results from sanger sequencing in 1,998 individuals.

by Martin Ladouceur, Zari Dastani, Yurii S Aulchenko, Celia M T Greenwood, J Brent Richards
Published 2012-02-01

An efficient paradigm for genetic epidemiology cohort creation.

by Martin Ladouceur, William D Leslie, Zari Dastani, David Goltzman, J Brent Richards
Published 2010-11-01

Large-scale genomics and proteomics to identify novel circulating biomarkers for bone density

by Sirui Zhou, John A. Morris, Erin Oerton, Vincenzo Forgetta, Claudia Langenberg, J. Brent Richards
Published 2020-10-01

Multiple regression methods show great potential for rare variant association tests.

by ChangJiang Xu, Martin Ladouceur, Zari Dastani, J Brent Richards, Antonio Ciampi, Celia M T Greenwood
Published 2012-01-01

Obesity and Multiple Sclerosis: A Mendelian Randomization Study.

by Lauren E Mokry, Stephanie Ross, Nicholas J Timpson, Stephen Sawcer, George Davey Smith, J Brent Richards
Published 2016-06-01

Performance of genotype imputation for low frequency and rare variants from the 1000 genomes.

by Hou-Feng Zheng, Jing-Jing Rong, Ming Liu, Fang Han, Xing-Wei Zhang, J Brent Richards, Li Wang
Published 2015-01-01

Little evidence for an effect of smoking on multiple sclerosis risk: A Mendelian Randomization study.

by Ruth E Mitchell, Kirsty Bates, Robyn E Wootton, Adil Harroud, J Brent Richards, George Davey Smith, Marcus R Munafò
Published 2020-11-01

Polygenic risk for coronary heart disease acts through atherosclerosis in type 2 diabetes

by Tianyuan Lu, Vincenzo Forgetta, Oriana H. Y. Yu, Lauren Mokry, Madeline Gregory, George Thanassoulis, Celia M. T. Greenwood, J. Brent Richards
Published 2020-01-01

Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study.

by Despoina Manousaki, Adil Harroud, Ruth E Mitchell, Stephanie Ross, Vince Forgetta, Nicholas J Timpson, George Davey Smith, Constantin Polychronakos, J Brent Richards
Published 2021-02-01

Correction: Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study.

by Despoina Manousaki, Adil Harroud, Ruth E Mitchell, Stephanie Ross, Vince Forgetta, Nicholas J Timpson, George Davey Smith, Constantin Polychronakos, J Brent Richards
Published 2021-04-01

Genetic interactions affecting human gene expression identified by variance association mapping

by Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin
Published 2014-04-01

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study.

by Lauren E Mokry, Stephanie Ross, Omar S Ahmad, Vincenzo Forgetta, George Davey Smith, David Goltzman, Aaron Leong, Celia M T Greenwood, George Thanassoulis, J Brent Richards
Published 2015-08-01

Correction: Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study.

by Lauren E Mokry, Stephanie Ross, Omar S Ahmad, Vincenzo Forgetta, George Davey Smith, David Goltzman, Aaron Leong, Celia M T Greenwood, George Thanassoulis, J Brent Richards
Published 2016-03-01

Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study.

by Despoina Manousaki, Lavinia Paternoster, Marie Standl, Miriam F Moffatt, Martin Farrall, Emmanuelle Bouzigon, David P Strachan, Florence Demenais, Mark Lathrop, William O C M Cookson, J Brent Richards
Published 2017-05-01

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study.

by Guillaume Butler-Laporte, Tomoko Nakanishi, Vincent Mooser, David R Morrison, Tala Abdullah, Olumide Adeleye, Noor Mamlouk, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Annarita Giliberti, Alessandra Renieri, Yiheng Chen, Sirui Zhou, Vincenzo Forgetta, J Brent Richards
Published 2021-06-01

The causal effect of vitamin D binding protein (DBP) levels on calcemic and cardiometabolic diseases: a Mendelian randomization study.

by Aaron Leong, Waheed Rehman, Zari Dastani, Celia Greenwood, Nicholas Timpson, Lisa Langsetmo, Claudie Berger, METASTROKE, Lei Fu, Betty Y L Wong, Suneil Malik, Rainer Malik, David A Hanley, David E C Cole, David Goltzman, J Brent Richards
Published 2014-10-01

Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based i...

by Andrew R Wood, John R B Perry, Toshiko Tanaka, Dena G Hernandez, Hou-Feng Zheng, David Melzer, J Raphael Gibbs, Michael A Nalls, Michael N Weedon, Tim D Spector, J Brent Richards, Stefania Bandinelli, Luigi Ferrucci, Andrew B Singleton, Timothy M Frayling
Published 2013-01-01

Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

by Tianyuan Lu, Vincenzo Forgetta, Julyan Keller-Baruch, Maria Nethander, Derrick Bennett, Marie Forest, Sahir Bhatnagar, Robin G. Walters, Kuang Lin, Zhengming Chen, Liming Li, Magnus Karlsson, Dan Mellström, Eric Orwoll, Eugene V. McCloskey, John A. Kanis, William D. Leslie, Robert J. Clarke, Claes Ohlsson, Celia M. T. Greenwood, J. Brent Richards
Published 2021-02-01

The use of genome-wide eQTL associations in lymphoblastoid cell lines to identify novel genetic pathways involved in complex traits.

by Josine L Min, Jennifer M Taylor, J Brent Richards, Tim Watts, Fredrik H Pettersson, John Broxholme, Kourosh R Ahmadi, Gabriela L Surdulescu, Ernesto Lowy, Christian Gieger, Chris Newton-Cheh, Markus Perola, Nicole Soranzo, Ida Surakka, Cecilia M Lindgren, Jiannis Ragoussis, Andrew P Morris, Lon R Cardon, Tim D Spector, Krina T Zondervan
Published 2011-01-01

RSPO3 is important for trabecular bone and fracture risk in mice and humans

by Karin H. Nilsson, Petra Henning, Maha El Shahawy, Maria Nethander, Thomas Levin Andersen, Charlotte Ejersted, Jianyao Wu, Karin L. Gustafsson, Antti Koskela, Juha Tuukkanen, Pedro P. C. Souza, Jan Tuckermann, Mattias Lorentzon, Linda Engström Ruud, Terho Lehtimäki, Jon H. Tobias, Sirui Zhou, Ulf H. Lerner, J. Brent Richards, Sofia Movérare-Skrtic, Claes Ohlsson
Published 2021-08-01