Severity of chronic experimental Chagas' heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease

by Isabela Resende Pereira, Glaucia Vilar-Pereira, Andrea Alice da Silva, Joseli Lannes-Vieira
Published 2014-06-01

Tumor Necrosis Factor Is a Therapeutic Target for Immunological Unbalance and Cardiac Abnormalities in Chronic Experimental Chagas’ Heart Disease

by Isabela Resende Pereira, Glaucia Vilar-Pereira, Andrea Alice Silva, Otacilio Cruz Moreira, Constança Britto, Ellen Diana Marinho Sarmento, Joseli Lannes-Vieira
Published 2014-01-01

Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins

by Laura Lacerda Coelho, Isabela Resende Pereira, Mirian Claudia de Souza Pereira, Liliane Mesquita, Joseli Lannes-Vieira, Daniel Adesse, Luciana Ribeiro Garzoni
Published 2018-01-01

CD8+ T-cells expressing interferon gamma or perforin play antagonistic roles in heart injury in experimental Trypanosoma cruzi-elicited cardiomyopathy.

by Jaline Coutinho Silverio, Isabela Resende Pereira, Márcio da Costa Cipitelli, Nathália Ferreira Vinagre, Maurício Martins Rodrigues, Ricardo Tostes Gazzinelli, Joseli Lannes-Vieira
Published 2012-01-01

Pentoxifylline reverses chronic experimental Chagasic cardiomyopathy in association with repositioning of abnormal CD8+ T-cell response.

by Isabela Resende Pereira, Glaucia Vilar-Pereira, Otacilio Cruz Moreira, Isalira Peroba Ramos, Daniel Gibaldi, Constança Britto, Milton Ozório Moraes, Joseli Lannes-Vieira
Published 2015-03-01

Chronic Trypanosoma cruzi-elicited cardiomyopathy: from the discovery to the proposal of rational therapeutic interventions targeting cell adhesion molecules and chemokine receptor...

by Joseli Lannes-Vieira, Jaline Coutinho Silverio, Isabela Resende Pereira, Nathália Ferreira Vinagre, Cristiano Marcelo Espinola Carvalho, Cláudia Neto Paiva, Andréa Alice da Silva
Published 2009-07-01

Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu

by Andrea Alice Silva, Rafael Rodrigues Silva, Daniel Gibaldi, Rafael Meyer Mariante, Jessica Brandão dos Santos, Isabela Resende Pereira, Otacílio Cruz Moreira, Joseli Lannes-Vieira
Published 2017-09-01

Treatment With Suboptimal Dose of Benznidazole Mitigates Immune Response Molecular Pathways in Mice With Chronic Chagas Cardiomyopathy

by Priscila Silva Grijó Farani, Priscila Silva Grijó Farani, Khodeza Begum, Glaucia Vilar-Pereira, Isabela Resende Pereira, Igor C. Almeida, Sourav Roy, Joseli Lannes-Vieira, Otacilio Cruz Moreira
Published 2021-07-01

Memory impairment in chronic experimental Chagas disease: Benznidazole therapy reversed cognitive deficit in association with reduction of parasite load and oxidative stress in the...

by Glaucia Vilar-Pereira, Leda Castaño Barrios, Andrea Alice da Silva, Angelica Martins Batista, Isabela Resende Pereira, Otacílio Cruz Moreira, Constança Britto, Hílton Antônio Mata Dos Santos, Joseli Lannes-Vieira
Published 2021-01-01

CCL3/Macrophage Inflammatory Protein-1α Is Dually Involved in Parasite Persistence and Induction of a TNF- and IFNγ-Enriched Inflammatory Milieu in Trypanosoma cruzi-Induced Chroni...

by Daniel Gibaldi, Glaucia Vilar-Pereira, Isabela Resende Pereira, Andrea Alice Silva, Leda Castaño Barrios, Isalira Peroba Ramos, Isalira Peroba Ramos, Hílton Antônio Mata dos Santos, Ricardo Gazzinelli, Joseli Lannes-Vieira
Published 2020-03-01

A human type 5 adenovirus-based Trypanosoma cruzi therapeutic vaccine re-programs immune response and reverses chronic cardiomyopathy.

by Isabela Resende Pereira, Glaucia Vilar-Pereira, Virgínia Marques, Andrea Alice da Silva, Bráulia Caetano, Otacilio Cruz Moreira, Alexandre Vieira Machado, Oscar Bruna-Romero, Maurício Martins Rodrigues, Ricardo Tostes Gazzinelli, Joseli Lannes-Vieira
Published 2015-01-01

Single nucleotide polymorphisms of cytokine-related genes and association with clinical outcome in a Chagas disease case-control study from Brazil

by Lucia Elena Alvarado-Arnez, Angelica Martins Batista, Silvia Marinho Alves, Gloria Melo, Virgínia Maria Barros de Lorena, Cynthia C Cardoso, Isabela Resende Pereira, Cristina Carrazzone, Antonio G Pacheco, Wilson Oliveira Jr, Milton Ozório Moraes, Joseli Lannes-Vieira
Published 2018-05-01

Inducible nitric oxide synthase in heart tissue and nitric oxide in serum of Trypanosoma cruzi-infected rhesus monkeys: association with heart injury.

by Cristiano Marcelo Espinola Carvalho, Jaline Coutinho Silverio, Andrea Alice da Silva, Isabela Resende Pereira, Janice Mery Chicarino Coelho, Constança Carvalho Britto, Otacílio Cruz Moreira, Renato Sergio Marchevsky, Sergio Salles Xavier, Ricardo Tostes Gazzinelli, Maria da Glória Bonecini-Almeida, Joseli Lannes-Vieira
Published 2012-01-01

MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes.

by Isabela Cunha Navarro, Frederico Moraes Ferreira, Helder I Nakaya, Monique Andrade Baron, Gláucia Vilar-Pereira, Isabela Resende Pereira, Ana Maria Gonçalves Silva, Juliana Monte Real, Thales De Brito, Christophe Chevillard, Joseli Lannes-Vieira, Jorge Kalil, Edecio Cunha-Neto, Ludmila Rodrigues Pinto Ferreira
Published 2015-01-01

Genetic Polymorphism at CCL5 Is Associated With Protection in Chagas’ Heart Disease: Antagonistic Participation of CCR1+ and CCR5+ Cells in Chronic Chagasic Cardiomyopathy

by Angelica Martins Batista, Lucia Elena Alvarado-Arnez, Lucia Elena Alvarado-Arnez, Silvia Marinho Alves, Gloria Melo, Isabela Resende Pereira, Leonardo Alexandre de Souza Ruivo, Andrea Alice da Silva, Daniel Gibaldi, Thayse do E. S. Protásio da Silva, Virginia Maria Barros de Lorena, Adriene Siqueira de Melo, Ana Karine de Araújo Soares, Michelle da Silva Barros, Vláudia Maria Assis Costa, Vláudia Maria Assis Costa, Cynthia C. Cardoso, Antonio G. Pacheco, Cristina Carrazzone, Wilson Oliveira, Milton Ozório Moraes, Joseli Lannes-Vieira
Published 2018-04-01