Matrilysin [MMP-7] Expression Selects for Cells with Reduced Sensitivity to Apoptosis

by Barbara Fingleton, Tracy Vargo-Gogola, Howard C. Crawford, Lynn M. Matrisian
Published 2001-01-01

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

by Alessio Colombo, Huanhuan Wang, Peer-Hendrik Kuhn, Richard Page, Elisabeth Kremmer, Peter J. Dempsey, Howard C. Crawford, Stefan F. Lichtenthaler
Published 2013-01-01

Persistent salmonellosis causes pancreatitis in a murine model of infection.

by Kathleen E DelGiorno, Jason W Tam, Jason C Hall, Gangadaar Thotakura, Howard C Crawford, Adrianus W M van der Velden
Published 2014-01-01

Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions

by Geou-Yarh Liou, Heike Döppler, Kathleen E. DelGiorno, Lizhi Zhang, Michael Leitges, Howard C. Crawford, Michael P. Murphy, Peter Storz
Published 2016-03-01

Mitogen-activated Protein Kinase Kinase Activity Maintains Acinar-to-Ductal Metaplasia and Is Required for Organ Regeneration in PancreatitisSummary

by Christopher J. Halbrook, Hui-Ju Wen, Jeanine M. Ruggeri, Kenneth K. Takeuchi, Yaqing Zhang, Marina Pasca di Magliano, Howard C. Crawford
Published 2017-01-01

Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption.

by Jun Liu, Ming Gao, Michael Nipper, Janice Deng, Francis E Sharkey, Randy L Johnson, Howard C Crawford, Yidong Chen, Pei Wang
Published 2019-09-01

Epithelial-Myeloid cell crosstalk regulates acinar cell plasticity and pancreatic remodeling in mice

by Yaqing Zhang, Wei Yan, Esha Mathew, Kevin T Kane, Arthur Brannon III, Maeva Adoumie, Alekya Vinta, Howard C Crawford, Marina Pasca di Magliano
Published 2017-10-01

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia.

by Michele L Scotti, Kristin E Smith, Amanda M Butler, Shelly R Calcagno, Howard C Crawford, Michael Leitges, Alan P Fields, Nicole R Murray
Published 2012-01-01

Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After PancreatitisSummary

by Hui-Ju Wen, Shan Gao, Yin Wang, Michael Ray, Mark A. Magnuson, Christopher V.E. Wright, Marina Pasca Di Magliano, Timothy L. Frankel, Howard C. Crawford
Published 2019-01-01

Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.

by Wahida H Ali, Qin Chen, Kathleen E Delgiorno, Wenjuan Su, Jason C Hall, Tsunaki Hongu, Huasong Tian, Yasunori Kanaho, Gilbert Di Paolo, Howard C Crawford, Michael A Frohman
Published 2013-01-01

Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis

by Benjamin Cyge, Vera Voronina, Mohammed Hoque, Eunice N. Kim, Jason Hall, Jennifer M. Bailey-Lundberg, Gregory J. Pazour, Howard C. Crawford, Randall T. Moon, Feng-Qian Li, Ken-Ichi Takemaru
Published 2021-08-01

Differential Contribution of Pancreatic Fibroblast Subsets to the Pancreatic Cancer StromaSummary

by Paloma E. Garcia, Maeva Adoumie, Esther C. Kim, Yaqing Zhang, Michael K. Scales, Yara S. El-Tawil, Amara Z. Shaikh, Hui-Ju Wen, Filip Bednar, Ben L. Allen, Deneen M. Wellik, Howard C. Crawford, Marina Pasca di Magliano
Published 2020-01-01

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

by Ethan V Abel, Masashi Goto, Brian Magnuson, Saji Abraham, Nikita Ramanathan, Emily Hotaling, Anthony A Alaniz, Chandan Kumar-Sinha, Michele L Dziubinski, Sumithra Urs, Lidong Wang, Jiaqi Shi, Meghna Waghray, Mats Ljungman, Howard C Crawford, Diane M Simeone
Published 2018-08-01

An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development

by Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan
Published 2020-06-01

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

by Amy S. Farrell, Meghan Morrison Joly, Brittany L. Allen-Petersen, Patrick J. Worth, Christian Lanciault, David Sauer, Jason Link, Carl Pelz, Laura M. Heiser, Jennifer P. Morton, Nathiya Muthalagu, Megan T. Hoffman, Sara L. Manning, Erica D. Pratt, Nicholas D. Kendsersky, Nkolika Egbukichi, Taylor S. Amery, Mary C. Thoma, Zina P. Jenny, Andrew D. Rhim, Daniel J. Murphy, Owen J. Sansom, Howard C. Crawford, Brett C. Sheppard, Rosalie C. Sears
Published 2017-11-01

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

by Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl, Costas A. Lyssiotis
Published 2020-01-01

Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism

by Alex J. Bott, Jianliang Shen, Claudia Tonelli, Le Zhan, Nithya Sivaram, Ya-Ping Jiang, Xufen Yu, Vrushank Bhatt, Eric Chiles, Hua Zhong, Sara Maimouni, Weiwei Dai, Stephani Velasquez, Ji-An Pan, Nathiya Muthalagu, Jennifer Morton, Tracy G. Anthony, Hui Feng, Wouter H. Lamers, Daniel J. Murphy, Jessie Yanxiang Guo, Jian Jin, Howard C. Crawford, Lanjing Zhang, Eileen White, Richard Z. Lin, Xiaoyang Su, David A. Tuveson, Wei-Xing Zong
Published 2019-10-01

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

by Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive, Costas A. Lyssiotis
Published 2021-08-01