Towards Bioengineered Liver Stem Cell Transplantation Studies in a Preclinical Dog Model for Inherited Copper Toxicosis

by Hedwig S. Kruitwagen, Hille Fieten, Louis C. Penning
Published 2019-09-01

Canine Models for Copper Homeostasis Disorders

by Xiaoyan Wu, Peter A. J. Leegwater, Hille Fieten
Published 2016-02-01

Translation From Mice to Men: Are Dogs a Dodgy Intermediate?

by Hedwig S. Kruitwagen, Bart Spee, Hille Fieten, Frank G. van Steenbeek, Baukje A. Schotanus, Louis C. Penning
Published 2014-05-01

Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection

by Yunlong Li, Changbo Qu, Bart Spee, Ruyi Zhang, Louis C. Penning, Robert A. de Man, Maikel P. Peppelenbosch, Hille Fieten, Qiuwei Pan
Published 2020-04-01

Association of the canine ATP7A and ATP7B with hepatic copper accumulation in Dobermann dogs

by Xiaoyan Wu, Paul J. J. Mandigers, Adrian L. Watson, Ted S. G. A. M. van denIngh, Peter A. J. Leegwater, Hille Fieten
Published 2019-07-01

Association of circulating microRNA‐122 and microRNA‐29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers

by Manabu Sakai, Bart Spee, Guy C. M. Grinwis, Louis C. Penning, Monique E. vanWolferen, Luc J. W. van derLaan, Hille Fieten
Published 2019-01-01

Investigation of Genetic Modifiers of Copper Toxicosis in Labrador Retrievers

by Xiaoyan Wu, Elise R. den Boer, Manon Vos-Loohuis, Frank G. van Steenbeek, Glen R. Monroe, Isaäc J. Nijman, Peter. A. J. Leegwater, Hille Fieten
Published 2020-10-01

Serum 25-hydroxyvitamin D concentrations in dogs with gallbladder mucocele.

by Jared A Jaffey, Jodi Matheson, Kate Shumway, Christina Pacholec, Tarini Ullal, Lindsay Van den Bossche, Hille Fieten, Randy Ringold, Keun Jung Lee, Amy E DeClue
Published 2020-01-01

COMMD1-deficient dogs accumulate copper in hepatocytes and provide a good model for chronic hepatitis and fibrosis.

by Robert P Favier, Bart Spee, Baukje A Schotanus, Ted S G A M van den Ingh, Hille Fieten, Bas Brinkhof, Cornelia S Viebahn, Louis C Penning, Jan Rothuizen
Published 2012-01-01

Gene expression patterns in the progression of canine copper-associated chronic hepatitis.

by Karen Dirksen, Bart Spee, Louis C Penning, Ted S G A M van den Ingh, Iwan A Burgener, Adrian L Watson, Marian Groot Koerkamp, Jan Rothuizen, Frank G van Steenbeek, Hille Fieten
Published 2017-01-01

Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts.

by Giora van Straten, Frank G van Steenbeek, Guy C M Grinwis, Robert P Favier, Anne Kummeling, Ingrid H van Gils, Hille Fieten, Marian J A Groot Koerkamp, Frank C P Holstege, Jan Rothuizen, Bart Spee
Published 2014-01-01

Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids

by Sathidpak Nantasanti, Bart Spee, Hedwig S. Kruitwagen, Chen Chen, Niels Geijsen, Loes A. Oosterhoff, Monique E. van Wolferen, Nicolas Pelaez, Hille Fieten, Richard W. Wubbolts, Guy C. Grinwis, Jefferson Chan, Meritxell Huch, Robert R.G. Vries, Hans Clevers, Alain de Bruin, Jan Rothuizen, Louis C. Penning, Baukje A. Schotanus
Published 2015-11-01

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

by Paulina Bartuzi, Daniel D. Billadeau, Robert Favier, Shunxing Rong, Daphne Dekker, Alina Fedoseienko, Hille Fieten, Melinde Wijers, Johannes H. Levels, Nicolette Huijkman, Niels Kloosterhuis, Henk van der Molen, Gemma Brufau, Albert K. Groen, Alison M. Elliott, Jan Albert Kuivenhoven, Barbara Plecko, Gernot Grangl, Julie McGaughran, Jay D. Horton, Ezra Burstein, Marten H. Hofker, Bart van de Sluis
Published 2016-03-01

The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders

by Hille Fieten, Yadvinder Gill, Alan J. Martin, Mafalda Concilli, Karen Dirksen, Frank G. van Steenbeek, Bart Spee, Ted S. G. A. M. van den Ingh, Ellen C. C. P. Martens, Paola Festa, Giancarlo Chesi, Bart van de Sluis, Roderick H. J. H. Houwen, Adrian L. Watson, Yurii S. Aulchenko, Victoria L. Hodgkinson, Sha Zhu, Michael J. Petris, Roman S. Polishchuk, Peter A. J. Leegwater, Jan Rothuizen
Published 2016-01-01