Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans

by Jeffrey D. Browning, Jay D. Horton
Published 2010-11-01

Opening up new fronts in the fight against cholesterol

by Russell A DeBose-Boyd, Jay D Horton
Published 2013-04-01

Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice*[S]

by Young-Ah Moon, Robert E. Hammer, Jay D. Horton
Published 2009-03-01

PCSK9: a convertase that coordinates LDL catabolism

by Jay D. Horton, Jonathan C. Cohen, Helen H. Hobbs
Published 2009-01-01

Plasma PCSK9 preferentially reduces liver LDL receptors in mice*

by Aldo Grefhorst, Markey C. McNutt, Thomas A. Lagace, Jay D. Horton
Published 2008-06-01

Inhibition of PCSK9 does not improve lipopolysaccharide-induced mortality in mice

by Jean-Mathieu Berger, Angel Loza Valdes, Jesper Gromada, Norma Anderson, Jay D. Horton
Published 2017-08-01

Deletion of ELOVL6 blocks the synthesis of oleic acid but does not prevent the development of fatty liver or insulin resistance[S]

by Young-Ah Moon, Courtney R. Ochoa, Matthew A. Mitsche, Robert E. Hammer, Jay D. Horton
Published 2014-12-01

Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2−/− lipodystrophic mice independent of hepatocyte leptin receptors[S]

by Víctor A. Cortés, Kelly M. Cautivo, Shunxing Rong, Abhimanyu Garg, Jay D. Horton, Anil K. Agarwal
Published 2014-02-01

The impact of endotrophin on the progression of chronic liver disease

by Min Kim, Changhu Lee, Dae Yun Seo, Hyojung Lee, Jay D. Horton, Jiyoung Park, Philipp E. Scherer
Published 2020-10-01

Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice

by Chandna Vasandani, Abdallah I. Kafrouni, Antonella Caronna, Yuriy Bashmakov, Michael Gotthardt, Jay D. Horton, David K. Spady
Published 2002-05-01

AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue

by Kelly M. Cautivo, Carlos O. Lizama, Pablo J. Tapia, Anil K. Agarwal, Abhimanyu Garg, Jay D. Horton, Víctor A. Cortés
Published 2016-07-01

A high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice[S]

by Joao A.G. Duarte, Filipa Carvalho, Mackenzie Pearson, Jay D. Horton, Jeffrey D. Browning, John G. Jones, Shawn C. Burgess
Published 2014-12-01

Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice

by Anil K. Agarwal, Katie Tunison, Jasbir S. Dalal, Chi-Liang Eric Yen, Robert V. Jr.Farese, Jay D. Horton, Abhimanyu Garg
Published 2016-04-01

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

by Shunxing Rong, Víctor A Cortés, Shirya Rashid, Norma N Anderson, Jeffrey G McDonald, Guosheng Liang, Young-Ah Moon, Robert E Hammer, Jay D Horton
Published 2017-02-01

Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice[S]

by Albert G. Linden, Shili Li, Hwa Y. Choi, Fei Fang, Masashi Fukasawa, Kosaku Uyeda, Robert E. Hammer, Jay D. Horton, Luke J. Engelking, Guosheng Liang
Published 2018-03-01

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

by Kaori Minehira, Stephen G. Young, Claudio J. Villanueva, Laxman Yetukuri, Matej Oresic, Mark K. Hellerstein, Robert V. Farese, Jr., Jay D. Horton, Frederic Preitner, Bernard Thorens, Luc Tappy
Published 2008-09-01

Measurement of lipogenic flux by deuterium resolved mass spectrometry

by Xiaorong Fu, Stanisław Deja, Justin A. Fletcher, Norma N. Anderson, Monika Mizerska, Gonçalo Vale, Jeffrey D. Browning, Jay D. Horton, Jeffrey G. McDonald, Matthew A. Mitsche, Shawn C. Burgess
Published 2021-06-01

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease

by Lin Jia, Xiuli Chang, Shuwen Qian, Chen Liu, Caleb C. Lord, Newaz Ahmed, Charlotte E. Lee, Syann Lee, Laurent Gautron, Mack C. Mitchell, Jay D. Horton, Philipp E. Scherer, Joel K. Elmquist
Published 2018-08-01

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

by Yingfeng Deng, Zhao V. Wang, Ruth Gordillo, Yi Zhu, Aktar Ali, Chen Zhang, Xiaoding Wang, Mengle Shao, Zhuzhen Zhang, Puneeth Iyengar, Rana K. Gupta, Jay D. Horton, Joseph A. Hill, Philipp E. Scherer
Published 2018-05-01

Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression.

by Yun-Seung Jeong, Deokhoon Kim, Yong Seok Lee, Ha-Jung Kim, Jung-Youn Han, Seung-Soon Im, Hansook Kim Chong, Je-Keun Kwon, Yun-Ho Cho, Woo Kyung Kim, Timothy F Osborne, Jay D Horton, Hee-Sook Jun, Yong-Ho Ahn, Sung-Min Ahn, Ji-Young Cha
Published 2011-01-01