Aaptamines from the Marine Sponge Aaptos sp. Display Anticancer Activities in Human Cancer Cell Lines and Modulate AP-1-, NF-κB-, and p53-Dependent Transcriptional Activity in Mous...

by Sergey A. Dyshlovoy, Sergey N. Fedorov, Larisa K. Shubina, Alexandra S. Kuzmich, Carsten Bokemeyer, Gunhild Keller-von Amsberg, Friedemann Honecker
Published 2014-01-01

Aurora Kinase Inhibitor PHA-739358 Suppresses Growth of Hepatocellular Carcinoma In Vitro and in a Xenograft Mouse Model

by Daniel Benten, Gunhild Keller, Alexander Quaas, Jorg Schrader, Artur Gontarewicz, Stefan Balabanov, Melanie Braig, Henning Wege, Jurgen Moll, Ansgar W. Lohse, Tim H. Brummendorf
Published 2009-09-01

Combination of a proteomics approach and reengineering of meso scale network models for prediction of mode-of-action for tyrosine kinase inhibitors.

by Stefan Balabanov, Thomas Wilhelm, Simone Venz, Gunhild Keller, Christian Scharf, Heike Pospisil, Melanie Braig, Christine Barett, Carsten Bokemeyer, Reinhard Walther, Tim H Brümmendorf, Andreas Schuppert
Published 2013-01-01

Abcg2 overexpression represents a novel mechanism for acquired resistance to the multi-kinase inhibitor Danusertib in BCR-ABL-positive cells in vitro.

by Stefan Balabanov, Artur Gontarewicz, Gunhild Keller, Laura Raddrizzani, Melanie Braig, Roberta Bosotti, Jürgen Moll, Edgar Jost, Christine Barett, Imke Rohe, Carsten Bokemeyer, Tessa L Holyoake, Tim H Brümmendorf
Published 2011-04-01