3D reconstruction Angular orientation Automated detection Autopicking Convolution Convolutional neural network Convolutional neural networks Cryo-electron micrographs CryoEM Cryoelectron Microscopy Deep learning Different particle sizes Electron microscopy Electrons Evaluation metrics Image Processing, Computer-Assisted Image reconstruction Image segmentation Imaging, Three-Dimensional Low signal-to-noise ratio Neural Networks, Computer Particle picking Particle size Particle size analysis Performance metrics Probability density function Proteins Regression Regression Analysis Signal to noise ratio