Regulation of CAR and PXR Expression in Health and Disease

by Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin
Published 2020-10-01

Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR

by Sabine Gerbal-Chaloin, Philippe Briolotti, Martine Daujat-Chavanieu, Martin Krøyer Rasmussen
Published 2021-01-01

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.

by Martin Krøyer Rasmussen, Patrick Balaguer, Bo Ekstrand, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin
Published 2016-01-01

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

by Tomas Smutny, Jan Dusek, Lucie Hyrsova, Jana Nekvindova, Alzbeta Horvatova, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek
Published 2020-01-01

Diazepam Promotes Translocation of Human Constitutive Androstane Receptor (CAR) via Direct Interaction with the Ligand-Binding Domain

by Josef Skoda, Jan Dusek, Martin Drastik, Alzbeta Stefela, Klara Dohnalova, Karel Chalupsky, Tomas Smutny, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek
Published 2020-11-01

ARID1A loss in adult hepatocytes activates β-catenin-mediated erythropoietin transcription

by Rozenn Riou, Meriem Ladli, Sabine Gerbal-Chaloin, Pascale Bossard, Angélique Gougelet, Cécile Godard, Robin Loesch, Isabelle Lagoutte, Franck Lager, Julien Calderaro, Alexandre Dos Santos, Zhong Wang, Frédérique Verdier, Sabine Colnot
Published 2020-10-01

The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

by Nicolas Creusot, Matthieu Gassiot, Elina Alaterre, Barbara Chiavarina, Marina Grimaldi, Abdelhay Boulahtouf, Lucia Toporova, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Alice Matheux, Roger Rahmani, Céline Gongora, Alexandre Evrard, Philippe Pourquier, Patrick Balaguer
Published 2020-07-01

Cold Preservation of Human Adult Hepatocytes for Liver Cell Therapy

by Cedric Duret, Daniel Moreno, Anangi Balasiddaiah, Solene Roux, Phillipe Briolotti, Edith Raulet, Astrid Herrero, Helene Ramet, Christine Biron-Andreani, Sabine Gerbal-Chaloin, Jeanne Ramos, Francis Navarro, Jean Hardwigsen, Patrick Maurel, Rafael Aldabe, Martine Daujat-Chavanieu
Published 2015-12-01

Mitochondrial Complex I activity signals antioxidant response through ERK5

by Abrar Ul Haq Khan, Nerea Allende-Vega, Delphine Gitenay, Johan Garaude, Dang-Nghiem Vo, Sana Belkhala, Sabine Gerbal-Chaloin, Claire Gondeau, Martine Daujat-Chavanieu, Cécile Delettre, Stefania Orecchioni, Giovanna Talarico, Francesco Bertolini, Alberto Anel, José M. Cuezva, Jose A. Enriquez, Guillaume Cartron, Charles-Henri Lecellier, Javier Hernandez, Martin Villalba
Published 2018-05-01

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway

by Abrar Ul Haq Khan, Nerea Allende-Vega, Delphine Gitenay, Sabine Gerbal-Chaloin, Claire Gondeau, Dang-Nghiem Vo, Sana Belkahla, Stefania Orecchioni, Giovanna Talarico, Francesco Bertolini, Milica Bozic, Jose M. Valdivielso, Fabienne Bejjani, Isabelle Jariel, Isabel C. Lopez-Mejia, Lluis Fajas, Charles-Henri Lecellier, Javier Hernandez, Martine Daujat, Martin Villalba
Published 2017-09-01