Smallpox in the Post-Eradication Era

by Hermann Meyer, Rosina Ehmann, Geoffrey L. Smith
Published 2020-01-01

Golgi anti-apoptotic protein: a tale of camels, calcium, channels and cancer

by Guia Carrara, Maddy Parsons, Nuno Saraiva, Geoffrey L. Smith
Published 2017-01-01

Enhanced Efficacy of Vaccination With Vaccinia Virus in Old vs. Young Mice

by Evgeniya V. Shmeleva, Geoffrey L. Smith, Brian J. Ferguson
Published 2019-07-01

Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

by Jonas D. Albarnaz, Alice A. Torres, Geoffrey L. Smith
Published 2018-02-01

Inhibition of IkappaB kinase by vaccinia virus virulence factor B14.

by Ron A-J Chen, Grigory Ryzhakov, Samantha Cooray, Felix Randow, Geoffrey L Smith
Published 2008-02-01

Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2.

by Jennifer H Stuart, Rebecca P Sumner, Yongxu Lu, Joseph S Snowden, Geoffrey L Smith
Published 2016-12-01

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

by Brian J Ferguson, Daniel S Mansur, Nicholas E Peters, Hongwei Ren, Geoffrey L Smith
Published 2012-12-01

A new inhibitor of apoptosis from vaccinia virus and eukaryotes.

by Caroline Gubser, Daniele Bergamaschi, Michael Hollinshead, Xin Lu, Frank J M van Kuppeveld, Geoffrey L Smith
Published 2007-02-01

Inhibition of Translation Initiation by Protein 169: A Vaccinia Virus Strategy to Suppress Innate and Adaptive Immunity and Alter Virus Virulence.

by Pavla Strnadova, Hongwei Ren, Robert Valentine, Michela Mazzon, Trevor R Sweeney, Ian Brierley, Geoffrey L Smith
Published 2015-09-01

Vaccinia virus protein complex F12/E2 interacts with kinesin light chain isoform 2 to engage the kinesin-1 motor complex.

by David C J Carpentier, William N D Gao, Helen Ewles, Gareth W Morgan, Geoffrey L Smith
Published 2015-03-01

Stimulation of cell invasion by the Golgi Ion Channel GAAP/TMBIM4 via an H2O2-Dependent Mechanism

by Nuno Almeida, Guia Carrara, Carlos M. Palmeira, Ana S. Fernandes, Maddy Parsons, Geoffrey L. Smith, Nuno Saraiva
Published 2020-01-01

Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export.

by Gareth W Morgan, Michael Hollinshead, Brian J Ferguson, Brendan J Murphy, David C J Carpentier, Geoffrey L Smith
Published 2010-02-01

Quantitative Temporal Proteomic Analysis of Vaccinia Virus Infection Reveals Regulation of Histone Deacetylases by an Interferon Antagonist

by Lior Soday, Yongxu Lu, Jonas D. Albarnaz, Colin T.R. Davies, Robin Antrobus, Geoffrey L. Smith, Michael P. Weekes
Published 2019-05-01

Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.

by Leonie Unterholzner, Rebecca P Sumner, Marcin Baran, Hongwei Ren, Daniel S Mansur, Nollaig M Bourke, Felix Randow, Geoffrey L Smith, Andrew G Bowie
Published 2011-09-01

A mechanism for the inhibition of DNA-PK-mediated DNA sensing by a virus.

by Nicholas E Peters, Brian J Ferguson, Michela Mazzon, Aodhnait S Fahy, Ewelina Krysztofinska, Raquel Arribas-Bosacoma, Laurence H Pearl, Hongwei Ren, Geoffrey L Smith
Published 2013-01-01

Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence.

by Daniel S Mansur, Carlos Maluquer de Motes, Leonie Unterholzner, Rebecca P Sumner, Brian J Ferguson, Hongwei Ren, Pavla Strnadova, Andrew G Bowie, Geoffrey L Smith
Published 2013-02-01

DNA-PK Is Targeted by Multiple Vaccinia Virus Proteins to Inhibit DNA Sensing

by Simon R. Scutts, Stuart W. Ember, Hongwei Ren, Chao Ye, Christopher A. Lovejoy, Michela Mazzon, David L. Veyer, Rebecca P. Sumner, Geoffrey L. Smith
Published 2018-11-01

Structure and function of A41, a vaccinia virus chemokine binding protein.

by Mohammad W Bahar, Julia C Kenyon, Mike M Putz, Nicola G A Abrescia, James E Pease, Emma L Wise, David I Stuart, Geoffrey L Smith, Jonathan M Grimes
Published 2008-01-01

Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.

by Carlos Maluquer de Motes, Samantha Cooray, Hongwei Ren, Gabriel M F Almeida, Kieran McGourty, Mohammad W Bahar, David I Stuart, Jonathan M Grimes, Stephen C Graham, Geoffrey L Smith
Published 2011-12-01

Vaccinia virus proteins A52 and B14 Share a Bcl-2-like fold but have evolved to inhibit NF-kappaB rather than apoptosis.

by Stephen C Graham, Mohammad W Bahar, Samantha Cooray, Ron A-J Chen, Daniel M Whalen, Nicola G A Abrescia, David Alderton, Raymond J Owens, David I Stuart, Geoffrey L Smith, Jonathan M Grimes
Published 2008-08-01