Leader of the SAC: molecular mechanisms of Mps1/TTK regulation in mitosis

by Spyridon T. Pachis, Geert J. P. L. Kops
Published 2018-08-01

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint

by Eelco Tromer, Debora Bade, Berend Snel, Geert J. P. L. Kops
Published 2016-01-01

Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis.

by Tale Sliedrecht, Chao Zhang, Kevan M Shokat, Geert J P L Kops
Published 2010-04-01

Interactions between N-terminal Modules in MPS1 Enable Spindle Checkpoint Silencing

by Spyridon T. Pachis, Yoshitaka Hiruma, Eelco C. Tromer, Anastassis Perrakis, Geert J.P.L. Kops
Published 2019-02-01

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells

by Conrad von Schubert, Fabien Cubizolles, Jasmine M. Bracher, Tale Sliedrecht, Geert J.P.L. Kops, Erich A. Nigg
Published 2015-07-01

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

by Katharina Overlack, Ivana Primorac, Mathijs Vleugel, Veronica Krenn, Stefano Maffini, Ingrid Hoffmann, Geert J P L Kops, Andrea Musacchio
Published 2015-01-01

Compromised MPS1 Activity Induces Multipolar Spindle Formation in Oocytes From Aged Mares: Establishing the Horse as a Natural Animal Model to Study Age-Induced Oocyte Meiotic Spin...

by Marilena Rizzo, Marilena Rizzo, Tom A. E. Stout, Santo Cristarella, Marco Quartuccio, Geert J. P. L. Kops, Marta De Ruijter-Villani
Published 2021-05-01

Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes.

by Nannette Jelluma, Arjan B Brenkman, Ian McLeod, John R Yates, Don W Cleveland, René H Medema, Geert J P L Kops
Published 2008-01-01

Regulation of sterol carrier protein gene expression by the Forkhead transcription factor FOXO3a

by Tobias B. Dansen, Geert J.P.L. Kops, Simone Denis, Nannette Jelluma, Ronald J.A. Wanders, Johannes L. Bos, Boudewijn M.T. Burgering, Karel W.A. Wirtz
Published 2004-01-01

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization

by Jiao Wang, Zhizhi Wang, Tingting Yu, Huan Yang, David M. Virshup, Geert J. P. L. Kops, Sang Hyun Lee, Weihong Zhou, Xin Li, Wenqing Xu, Zihe Rao
Published 2016-06-01

Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.

by Loes A L van de Pasch, Antony J Miles, Wilco Nijenhuis, Nathalie A C H Brabers, Dik van Leenen, Philip Lijnzaad, Markus K Brown, Jimmy Ouellet, Yves Barral, Geert J P L Kops, Frank C P Holstege
Published 2013-01-01

Degree and site of chromosomal instability define its oncogenic potential

by Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma
Published 2020-03-01

Germline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis

by Pilar Mur, Richarda M. De Voer, Rubén Olivera-Salguero, Sandra Rodríguez-Perales, Tirso Pons, Fernando Setién, Gemma Aiza, Rafael Valdés-Mas, Angelo Bertini, Marta Pineda, Lilian Vreede, Matilde Navarro, Silvia Iglesias, Sara González, Joan Brunet, Alfonso Valencia, Manel Esteller, Conxi Lázaro, Geert J. P. L. Kops, Miguel Urioste, Xose S. Puente, Gabriel Capellá, Laura Valle
Published 2018-02-01

Chromosomal copy number heterogeneity predicts survival rates across cancers

by Erik van Dijk, Tom van den Bosch, Kristiaan J. Lenos, Khalid El Makrini, Lisanne E. Nijman, Hendrik F. B. van Essen, Nico Lansu, Michiel Boekhout, Joris H. Hageman, Rebecca C. Fitzgerald, Cornelis J. A. Punt, Jurriaan B. Tuynman, Hugo J. G. Snippert, Geert J. P. L. Kops, Jan Paul Medema, Bauke Ylstra, Louis Vermeulen, Daniël M. Miedema
Published 2021-05-01