TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

by Glen M Chew, Tsuyoshi Fujita, Gabriela M Webb, Benjamin J Burwitz, Helen L Wu, Jason S Reed, Katherine B Hammond, Kiera L Clayton, Naoto Ishii, Mohamed Abdel-Mohsen, Teri Liegler, Brooks I Mitchell, Frederick M Hecht, Mario Ostrowski, Cecilia M Shikuma, Scott G Hansen, Mark Maurer, Alan J Korman, Steven G Deeks, Jonah B Sacha, Lishomwa C Ndhlovu
Published 2016-01-01

The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaqu...

by Gabriela M Webb, Jhomary Molden, Kathleen Busman-Sahay, Shaheed Abdulhaqq, Helen L Wu, Whitney C Weber, Katherine B Bateman, Jason S Reed, Mina Northrup, Nicholas Maier, Shiho Tanaka, Lina Gao, Brianna Davey, Benjamin L Carpenter, Michael K Axthelm, Jeffrey J Stanton, Jeremy Smedley, Justin M Greene, Jeffrey T Safrit, Jacob D Estes, Pamela J Skinner, Jonah B Sacha
Published 2020-03-01

CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

by Bruce K. Patterson, Harish Seethamraju, Kush Dhody, Michael J. Corley, Kazem Kazempour, Jay Lalezari, Alina P.S. Pang, Christopher Sugai, Eisa Mahyari, Edgar B. Francisco, Amruta Pise, Hallison Rodrigues, Helen L. Wu, Gabriela M. Webb, Byung S. Park, Scott Kelly, Nader Pourhassan, Alina Lelic, Lama Kdouh, Monica Herrera, Eric Hall, Benjamin N. Bimber, Matthew Plassmeyer, Raavi Gupta, Oral Alpan, Jane A. O’Halloran, Philip A. Mudd, Enver Akalin, Lishomwa C. Ndhlovu, Jonah B. Sacha
Published 2021-02-01

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes

by Benjamin J. Burwitz, Helen L. Wu, Shaheed Abdulhaqq, Christine Shriver-Munsch, Tonya Swanson, Alfred W. Legasse, Katherine B. Hammond, Stephanie L. Junell, Jason S. Reed, Benjamin N. Bimber, Justin M. Greene, Gabriela M. Webb, Mina Northrup, Wolfram Laub, Paul Kievit, Rhonda MacAllister, Michael K. Axthelm, Rebecca Ducore, Anne Lewis, Lois M. A. Colgin, Theodore Hobbs, Lauren D. Martin, Betsy Ferguson, Charles R. Thomas Jr., Angela Panoskaltsis-Mortari, Gabrielle Meyers, Jeffrey J. Stanton, Richard T. Maziarz, Jonah B. Sacha
Published 2017-11-01

Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission

by Xiao L. Chang, Gabriela M. Webb, Helen L. Wu, Justin M. Greene, Shaheed Abdulhaqq, Katherine B. Bateman, Jason S. Reed, Cleiton Pessoa, Whitney C. Weber, Nicholas Maier, Glen M. Chew, Roxanne M. Gilbride, Lina Gao, Rebecca Agnor, Travis Giobbi, Jeffrey Torgerson, Don Siess, Nicole Burnett, Miranda Fischer, Oriene Shiel, Cassandra Moats, Bruce Patterson, Kush Dhody, Scott Kelly, Nader Pourhassan, Diogo M. Magnani, Jeremy Smedley, Benjamin N. Bimber, Nancy L. Haigwood, Scott G. Hansen, Timothy R. Brown, Lishomwa C. Ndhlovu, Jonah B. Sacha
Published 2021-06-01