Inhibitory FcyRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity

by Vaughan, A.T, Iriyama, C., Beers, S.A, Chan, C.H.T, Lim, S.H, Williams, E.L, Shah, V., Roghanian, A., Frendeus, B., Glennie, M.J, Cragg, M.S
Published 2014

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

by Beers, S.A, Booth, S.G, Carter, M.J, Chee, S.J, Cleary, K.L.S, Cragg, M.S, Cutress, R.I, Dahal, L.N, Douglas, J., Foxall, R.B, French, R.R, Frendéus, B., Ghorbani, M., Glennie, M.J, Hargreaves, C.E, Hussain, K., James, S., Kemp, R.S, Liu, R., Longley, J., Macari, S., Markham, H., Müller, K.T.J, Murray, T., Oldham, R.J, Ottensmeier, C.H, Roghanian, A., Smith, R.C.G, Stopforth, R.J, Strefford, J.C, Thirdborough, S.M
Published 2022

HIF activation enhances FcγRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy

by Beers, S.A, Booth, S.G, Carter, M.J, Chee, S.J, Cleary, K.L.S, Cragg, M.S, Cutress, R.I, Dahal, L.N, Douglas, J., Foxall, R.B, French, R.R, Frendéus, B., Ghorbani, M., Glennie, M.J, Hargreaves, C.E, Hussain, K., James, S., Kemp, R.S, Liu, R., Longley, J., Macari, S., Markham, H., Müller, K.T.J, Murray, T., Oldham, R.J, Ottensmeier, C.H, Roghanian, A., Smith, R.C.G, Stopforth, R.J, Strefford, J.C, Thirdborough, S.M
Published 2022