Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.

by Thomas Perlot, Inka Pawlitzky, John P Manis, Ali A Zarrin, Peter H Brodeur, Frederick W Alt
Published 2010-11-01

Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.

by Roza Selimyan, Rachel M Gerstein, Irina Ivanova, Patricia Precht, Ramesh Subrahmanyam, Thomas Perlot, Frederick W Alt, Ranjan Sen
Published 2013-01-01

Abnormalities of thymic stroma may contribute to immune dysregulation in murine models of leaky severe combined immunodeficiency

by Francesca eRucci, Pietro Luigi Poliani, Stefano eCaraffi, Tiziana ePaganini, Elena eFontana, Silvia eGiliani, Frederick W Alt, Luigi Daniele Notarangelo
Published 2011-05-01

An Oncogenic Role for Alternative NF-κB Signaling in DLBCL Revealed upon Deregulated BCL6 Expression

by Baochun Zhang, Dinis Pedro Calado, Zhe Wang, Sebastian Fröhler, Karl Köchert, Yu Qian, Sergei B. Koralov, Marc Schmidt-Supprian, Yoshiteru Sasaki, Christine Unitt, Scott Rodig, Wei Chen, Riccardo Dalla-Favera, Frederick W. Alt, Laura Pasqualucci, Klaus Rajewsky
Published 2015-05-01

Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.

by Wei Shi, Amanda L Bain, Bjoern Schwer, Fares Al-Ejeh, Corey Smith, Lee Wong, Hua Chai, Mariska S Miranda, Uda Ho, Makoto Kawaguchi, Yutaka Miura, John W Finnie, Meaghan Wall, Jörg Heierhorst, Carol Wicking, Kevin J Spring, Frederick W Alt, Kum Kum Khanna
Published 2013-01-01

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

by Jiyung Shin, Ming He, Yufei Liu, Silvana Paredes, Lidia Villanova, Katharine Brown, Xiaolei Qiu, Noushin Nabavi, Mary Mohrin, Kathleen Wojnoonski, Patrick Li, Hwei-Ling Cheng, Andrew J. Murphy, David M. Valenzuela, Hanzhi Luo, Pankaj Kapahi, Ronald Krauss, Raul Mostoslavsky, George D. Yancopoulos, Frederick W. Alt, Katrin F. Chua, Danica Chen
Published 2013-11-01

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

by Jiyung Shin, Ming He, Yufei Liu, Silvana Paredes, Lidia Villanova, Katharine Brown, Xiaolei Qiu, Noushin Nabavi, Mary Mohrin, Kathleen Wojnoonski, Patrick Li, Hwei-Ling Cheng, Andrew J. Murphy, David M. Valenzuela, Hanzhi Luo, Pankaj Kapahi, Ronald Krauss, Raul Mostoslavsky, George D. Yancopoulos, Frederick W. Alt, Katrin F. Chua, Danica Chen
Published 2013-12-01

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

by Manasi Ratnaparkhe, John K. L. Wong, Pei-Chi Wei, Mario Hlevnjak, Thorsten Kolb, Milena Simovic, Daniel Haag, Yashna Paul, Frauke Devens, Paul Northcott, David T. W. Jones, Marcel Kool, Anna Jauch, Agata Pastorczak, Wojciech Mlynarski, Andrey Korshunov, Rajiv Kumar, Susanna M. Downing, Stefan M. Pfister, Marc Zapatka, Peter J. McKinnon, Frederick W. Alt, Peter Lichter, Aurélie Ernst
Published 2018-11-01

Immune checkpoint modulation enhances HIV-1 antibody induction

by Todd Bradley, Masayuki Kuraoka, Chen-Hao Yeh, Ming Tian, Huan Chen, Derek W. Cain, Xuejun Chen, Cheng Cheng, Ali H. Ellebedy, Robert Parks, Maggie Barr, Laura L. Sutherland, Richard M. Scearce, Cindy M. Bowman, Hilary Bouton-Verville, Sampa Santra, Kevin Wiehe, Mark G. Lewis, Ane Ogbe, Persephone Borrow, David Montefiori, Mattia Bonsignori, M. Anthony Moody, Laurent Verkoczy, Kevin O. Saunders, Rafi Ahmed, John R. Mascola, Garnett Kelsoe, Frederick W. Alt, Barton F. Haynes
Published 2020-02-01