Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery.

by Anna F Fesser, Olivier Braissant, Francisco Olmo, John M Kelly, Pascal Mäser, Marcel Kaiser
Published 2020-07-01

Trypanosoma cruzi amastigotes that persist in the colon during chronic stage murine infections have a reduced replication rate

by Alexander I. Ward, Francisco Olmo, Richard L. Atherton, Martin C. Taylor, John M. Kelly
Published 2020-12-01

An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase

by Francisco Olmo, Kristína Urbanová, Maria Jose Rosales, Ruben Martín-Escolano, Manuel Sánchez-Moreno, Clotilde Marín
Published 2015-12-01

Image-Based In Vitro Screening Reveals the Trypanostatic Activity of Hydroxymethylnitrofurazone against <i>Trypanosoma cruzi</i>

by Cauê Benito Scarim, Francisco Olmo, Elizabeth Igne Ferreira, Chung Man Chin, John M. Kelly, Amanda Fortes Francisco
Published 2021-06-01

Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection.

by Martin C Taylor, Alexander Ward, Francisco Olmo, Shiromani Jayawardhana, Amanda F Francisco, Michael D Lewis, John M Kelly
Published 2020-03-01

Challenges in Chagas Disease Drug Development

by Amanda F. Francisco, Shiromani Jayawardhana, Francisco Olmo, Michael D. Lewis, Shane R. Wilkinson, Martin C. Taylor, John M. Kelly
Published 2020-06-01

In vitro evaluation of new terpenoid derivatives against Leishmania infantum and Leishmania braziliensis

by Inmaculada Ramírez-Macías, Clotilde Marín, Rachid Chahboun, Francisco Olmo, Ibtisam Messouri, Oscar Huertas, María Jose Rosales, Ramón Gutierrez-Sánchez, Enrique Alvarez-Manzaneda, Manuel Sánchez-Moreno
Published 2012-05-01

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo...

by Fernanda Cristina Costa, Amanda Fortes Francisco, Shiromani Jayawardhana, Simone Guedes Calderano, Michael D Lewis, Francisco Olmo, Tom Beneke, Eva Gluenz, Jack Sunter, Samuel Dean, John Morrison Kelly, Martin Craig Taylor
Published 2018-04-01

Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection.

by Gurdip Singh Mann, Amanda F Francisco, Shiromani Jayawardhana, Martin C Taylor, Michael D Lewis, Francisco Olmo, Elisangela Oliveira de Freitas, Fabiana M S Leoratti, Cesar López-Camacho, Arturo Reyes-Sandoval, John M Kelly
Published 2020-04-01