“An End to a Means”: How DNA-End Structure Shapes the Double-Strand Break Repair Process

by Almudena Serrano-Benítez, Felipe Cortés-Ledesma, Felipe Cortés-Ledesma, Jose F. Ruiz, Jose F. Ruiz
Published 2020-01-01

Does Tyrosyl DNA Phosphodiesterase-2 Play a Role in Hepatitis B Virus Genome Repair?

by Xiuji Cui, Rebecca McAllister, Rajeev Boregowda, Ji A Sohn, Felipe Cortes Ledesma, Keith W Caldecott, Christoph Seeger, Jianming Hu
Published 2015-01-01

Genome-wide prediction of topoisomerase IIβ binding by architectural factors and chromatin accessibility.

by Pedro Manuel Martínez-García, Miguel García-Torres, Federico Divina, José Terrón-Bautista, Irene Delgado-Sainz, Francisco Gómez-Vela, Felipe Cortés-Ledesma
Published 2021-01-01

Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing

by Andrés Herrero-Ruiz, Pedro Manuel Martínez-García, José Terrón-Bautista, Gonzalo Millán-Zambrano, Jenna Ariel Lieberman, Silvia Jimeno-González, Felipe Cortés-Ledesma
Published 2021-04-01

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks

by Pierre Caron, Jonathan Choudjaye, Thomas Clouaire, Béatrix Bugler, Virginie Daburon, Marion Aguirrebengoa, Thomas Mangeat, Jason S. Iacovoni, Alejandro Álvarez-Quilón, Felipe Cortés-Ledesma, Gaëlle Legube
Published 2015-11-01

TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.

by Fernando Gómez-Herreros, Rocío Romero-Granados, Zhihong Zeng, Alejandro Alvarez-Quilón, Cristina Quintero, Limei Ju, Lieve Umans, Liesbeth Vermeire, Danny Huylebroeck, Keith W Caldecott, Felipe Cortés-Ledesma
Published 2013-01-01

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency

by Alejandro Álvarez-Quilón, José Terrón-Bautista, Irene Delgado-Sainz, Almudena Serrano-Benítez, Rocío Romero-Granados, Pedro Manuel Martínez-García, Silvia Jimeno-González, Cristina Bernal-Lozano, Cristina Quintero, Lourdes García-Quintanilla, Felipe Cortés-Ledesma
Published 2020-02-01

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme

by Weijun Feng, Daisuke Kawauchi, Huiqin Körkel-Qu, Huan Deng, Elisabeth Serger, Laura Sieber, Jenna Ariel Lieberman, Silvia Jimeno-González, Sander Lambo, Bola S. Hanna, Yassin Harim, Malin Jansen, Anna Neuerburg, Olga Friesen, Marc Zuckermann, Vijayanad Rajendran, Jan Gronych, Olivier Ayrault, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Peter Lichter, Felipe Cortés-Ledesma, Stefan M. Pfister, Hai-Kun Liu
Published 2017-03-01