Inhibition of TLR4 Signaling Impedes Tumor Growth in Colitis-Associated Colon Cancer

by Eva Pastille, Tabea Faßnacht, Alexandra Adamczyk, Nhi Ngo Thi Phuong, Jan Buer, Astrid M. Westendorf
Published 2021-05-01

Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge.

by Florian Wirsdörfer, Jörg M Bangen, Eva Pastille, Daniel Schmitz, Sascha Flohé, Beatrix Schumak, Stefanie B Flohé
Published 2016-01-01

Distinct kinetics in the frequency of peripheral CD4+ T cells in patients with ulcerative colitis experiencing a flare during treatment with mesalazine or with a herbal preparation...

by Jost Langhorst, Annika Frede, Markus Knott, Eva Pastille, Jan Buer, Gustav J Dobos, Astrid M Westendorf
Published 2014-01-01

Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity

by Astrid M. Westendorf, Kathrin Skibbe, Alexandra Adamczyk, Jan Buer, Robert Geffers, Wiebke Hansen, Eva Pastille, Verena Jendrossek
Published 2017-03-01

IL-33 Drives Expansion of Type 2 Innate Lymphoid Cells and Regulatory T Cells and Protects Mice From Severe, Acute Colitis

by Nhi Ngo Thi Phuong, Vittoria Palmieri, Alexandra Adamczyk, Robert Klopfleisch, Jost Langhorst, Wiebke Hansen, Astrid M. Westendorf, Eva Pastille
Published 2021-07-01

Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer.

by Eva Pastille, Annika Frede, Henry J McSorley, Jessica Gräb, Alexandra Adamczyk, Sebastian Kollenda, Wiebke Hansen, Matthias Epple, Jan Buer, Rick M Maizels, Robert Klopfleisch, Astrid M Westendorf
Published 2017-09-01

Sphingosine 1-Phosphate- and C-C Chemokine Receptor 2-Dependent Activation of CD4+ Plasmacytoid Dendritic Cells in the Bone Marrow Contributes to Signs of Sepsis-Induced Immunosupp...

by Anna Smirnov, Stephanie Pohlmann, Melanie Nehring, Shafaqat Ali, Shafaqat Ali, Ritu Mann-Nüttel, Stefanie Scheu, Anne-Charlotte Antoni, Wiebke Hansen, Manuela Büettner, Miriam J. Gardiasch, Astrid M. Westendorf, Florian Wirsdörfer, Eva Pastille, Marcel Dudda, Stefanie B. Flohé
Published 2017-11-01

Combination immunotherapy with anti-PD-L1 antibody and depletion of regulatory T cells during acute viral infections results in improved virus control but lethal immunopathology.

by Paul David, Malgorzata Drabczyk-Pluta, Eva Pastille, Torben Knuschke, Tanja Werner, Nadine Honke, Dominik A Megger, Ilseyar Akhmetzyanova, Namir Shaabani, Annette Eyking-Singer, Elke Cario, Olivia Kershaw, Achim D Gruber, Matthias Tenbusch, Kirsten K Dietze, Mirko Trilling, Jia Liu, Dirk Schadendorf, Hendrik Streeck, Karl S Lang, Youhua Xie, Lisa Zimmer, Barbara Sitek, Annette Paschen, Astrid M Westendorf, Ulf Dittmer, Gennadiy Zelinskyy
Published 2020-03-01