Preclinical Efficacy of a Trivalent Human FcγRI-Targeted Adjuvant-Free Subunit Mucosal Vaccine against Pulmonary Pneumococcal Infection

by Sudeep Kumar, Raju Sunagar, Edmund J. Gosselin
Published 2020-04-01

Targeting of a Fixed Bacterial Immunogen to Fc Receptors Reverses the Anti-Inflammatory Properties of the Gram-Negative Bacterium, Francisella tularensis, during the Early Stages o...

by Zulfia Babadjanova, Kari Wiedinger, Edmund J Gosselin, Constantine Bitsaktsis
Published 2015-01-01

Differential In Vitro Cultivation of Francisella tularensis Influences Live Vaccine Protective Efficacy by Altering the Immune Response

by Raju Sunagar, Sudeep Kumar, Sarah J. Rosa, Karsten R. O. Hazlett, Edmund J. Gosselin
Published 2018-07-01

Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing.

by Raju Sunagar, Sudeep Kumar, Prachi Namjoshi, Sarah J Rosa, Karsten R O Hazlett, Edmund J Gosselin
Published 2018-01-01

Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB

by Brian J. Franz, Ying Li, Constantine Bitsaktsis, Bibiana V. Iglesias, Giang Pham, Raju Sunagar, Sudeep Kumar, Edmund J. Gosselin
Published 2015-01-01

Preclinical testing of a vaccine candidate against tularemia.

by Ragavan Varadharajan Suresh, Zhuo Ma, Raju Sunagar, Vivek Bhatty, Sukalyani Banik, Sally V Catlett, Edmund J Gosselin, Meenakshi Malik, Chandra Shekhar Bakshi
Published 2015-01-01

Host-adaptation of Francisella tularensis alters the bacterium's surface-carbohydrates to hinder effectors of innate and adaptive immunity.

by Tiffany M Zarrella, Anju Singh, Constantine Bitsaktsis, Tabassum Rahman, Bikash Sahay, Paul J Feustel, Edmund J Gosselin, Timothy J Sellati, Karsten R O Hazlett
Published 2011-01-01

Autotransporter-Mediated Display of Complement Receptor Ligands by Gram-Negative Bacteria Increases Antibody Responses and Limits Disease Severity

by Kristen M Holland-Tummillo, Lauren E Shoudy, Donald Steiner, Sudeep Kumar, Sarah J Rosa, Prachi Namjoshi, Anju Singh, Timothy J Sellati, Edmund J Gosselin, Karsten RO Hazlett
Published 2020-05-01

Differential Growth of Francisella tularensis, Which Alters Expression of Virulence Factors, Dominant Antigens, and Surface-Carbohydrate Synthases, Governs the Apparent Virulence o...

by Kristen M. Holland, Sarah J. Rosa, Kolbrun Kristjansdottir, Donald Wolfgeher, Brian J. Franz, Tiffany M. Zarrella, Sudeep Kumar, Raju Sunagar, Anju Singh, Chandra S. Bakshi, Prachi Namjoshi, Eileen M. Barry, Timothy J. Sellati, Stephen J. Kron, Edmund J. Gosselin, Douglas S. Reed, Karsten R. O. Hazlett
Published 2017-06-01