Network reconstruction based on proteomic data and prior knowledge of protein connectivity using graph theory.

by Vassilis Stavrakas, Ioannis N Melas, Theodore Sakellaropoulos, Leonidas G Alexopoulos
Published 2015-01-01

Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs.

by Ioannis N Melas, Regina Samaga, Leonidas G Alexopoulos, Steffen Klamt
Published 2013-01-01

Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data.

by Alexander Mitsos, Ioannis N Melas, Paraskeuas Siminelakis, Aikaterini D Chairakaki, Julio Saez-Rodriguez, Leonidas G Alexopoulos
Published 2009-12-01

Non Linear Programming (NLP) formulation for quantitative modeling of protein signal transduction pathways.

by Alexander Mitsos, Ioannis N Melas, Melody K Morris, Julio Saez-Rodriguez, Douglas A Lauffenburger, Leonidas G Alexopoulos
Published 2012-01-01