Mitochondrial Genes in Degenerative Disease and Aging

by Douglas C. Wallace
Published 2001-01-01

Microchambers with Solid-State Phosphorescent Sensor for Measuring Single Mitochondrial Respiration

by Ted D. Pham, Douglas C. Wallace, Peter J. Burke
Published 2016-07-01

TSPO, a Mitochondrial Outer Membrane Protein, Controls Ethanol-Related Behaviors in Drosophila.

by Ran Lin, Danielle Rittenhouse, Katelyn Sweeney, Prasanth Potluri, Douglas C Wallace
Published 2015-08-01

Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production.

by Sha Tang, Phung Khanh Le, Stephanie Tse, Douglas C Wallace, Taosheng Huang
Published 2009-01-01

Predicting the pathogenicity of novel variants in mitochondrial tRNA with MitoTIP.

by Sanjay Sonney, Jeremy Leipzig, Marie T Lott, Shiping Zhang, Vincent Procaccio, Douglas C Wallace, Neal Sondheimer
Published 2017-12-01

Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury in a Porcine Model.

by Todd J Kilbaugh, Maria Lvova, Michael Karlsson, Zhe Zhang, Jeremy Leipzig, Douglas C Wallace, Susan S Margulies
Published 2015-01-01

Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders

by Erika G. Lin-Hendel, Meagan J. McManus, Douglas C. Wallace, Stewart A. Anderson, Jeffrey A. Golden
Published 2016-04-01

Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity.

by Lydia W S Finley, Wilhelm Haas, Valérie Desquiret-Dumas, Douglas C Wallace, Vincent Procaccio, Steven P Gygi, Marcia C Haigis
Published 2011-01-01

Ancient mtDNA genetic variants modulate mtDNA transcription and replication.

by Sarit Suissa, Zhibo Wang, Jason Poole, Sharine Wittkopp, Jeanette Feder, Timothy E Shutt, Douglas C Wallace, Gerald S Shadel, Dan Mishmar
Published 2009-05-01

The molecular mechanisms of OPA1-mediated optic atrophy in Drosophila model and prospects for antioxidant treatment.

by Will Yarosh, Jessica Monserrate, James Jiayuan Tong, Stephanie Tse, Phung Khanh Le, Kimberly Nguyen, Carrie B Brachmann, Douglas C Wallace, Taosheng Huang
Published 2008-01-01

NADH Fluorescence Lifetime Imaging Microscopy Reveals Selective Mitochondrial Dysfunction in Neurons Overexpressing Alzheimer’s Disease–Related Proteins

by Moritz A. Niederschweiberer, Moritz A. Niederschweiberer, Patrick M. Schaefer, Patrick M. Schaefer, Larry N. Singh, Ludwig Lausser, Devyani Bhosale, Raphael Hesse, Enrico Calzia, Hans A. Kestler, Angelika Rueck, Douglas C. Wallace, Douglas C. Wallace, Bjoern von Einem, Christine A. F. von Arnim, Christine A. F. von Arnim
Published 2021-06-01

An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation

by Rebecca S. Arnold, Qian Sun, Carrie Q. Sun, Jendai C. Richards, Sean O'Hearn, Adeboye O. Osunkoya, Douglas C. Wallace, John A. Petros
Published 2013-01-01

Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase

by Jeremy G Bird, Urmimala Basu, David Kuster, Aparna Ramachandran, Ewa Grudzien-Nogalska, Atif Towheed, Douglas C Wallace, Megerditch Kiledjian, Dmitry Temiakov, Smita S Patel, Richard H Ebright, Bryce E Nickels
Published 2018-12-01

VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease.

by Mallikarjun Badadani, Angèle Nalbandian, Giles D Watts, Jouni Vesa, Masashi Kitazawa, Hailing Su, Jasmin Tanaja, Eric Dec, Douglas C Wallace, Jogeshwar Mukherjee, Vincent Caiozzo, Matthew Warman, Virginia E Kimonis
Published 2010-10-01

BK_Ca (<i>Slo</i>) Channel Regulates Mitochondrial Function and Lifespan in <i>Drosophila melanogaster</i>

by Shubha Gururaja Rao, Piotr Bednarczyk, Atif Towheed, Kajol Shah, Priyanka Karekar, Devasena Ponnalagu, Haley N. Jensen, Sankar Addya, Beverly A.S. Reyes, Elisabeth J. Van Bockstaele, Adam Szewczyk, Douglas C. Wallace, Harpreet Singh
Published 2019-08-01

Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder.

by Brandi Rollins, Maureen V Martin, P Adolfo Sequeira, Emily A Moon, Ling Z Morgan, Stanley J Watson, Alan Schatzberg, Huda Akil, Richard M Myers, Edward G Jones, Douglas C Wallace, William E Bunney, Marquis P Vawter
Published 2009-01-01

Mitochondrial DNA variants mediate energy production and expression levels for CFH, C3 and EFEMP1 genes: implications for age-related macular degeneration.

by M Cristina Kenney, Marilyn Chwa, Shari R Atilano, Janelle M Pavlis, Payam Falatoonzadeh, Claudio Ramirez, Deepika Malik, Tiffany Hsu, Grace Woo, Kyaw Soe, Anthony B Nesburn, David S Boyer, Baruch D Kuppermann, S Michal Jazwinski, Michael V Miceli, Douglas C Wallace, Nitin Udar
Published 2013-01-01

Human retinal transmitochondrial cybrids with J or H mtDNA haplogroups respond differently to ultraviolet radiation: implications for retinal diseases.

by Deepika Malik, Tiffany Hsu, Payam Falatoonzadeh, Javier Cáceres-del-Carpio, Mohamed Tarek, Marilyn Chwa, Shari R Atilano, Claudio Ramirez, Anthony B Nesburn, David S Boyer, Baruch D Kuppermann, S Michal Jazwinski, Michael V Miceli, Douglas C Wallace, Nitin Udar, M Cristina Kenney
Published 2014-01-01

Lactate Limits T Cell Proliferation via the NAD(H) Redox State

by William J. Quinn, III, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroline Perry, Piotr K. Kopinski, Lili Guo, Ian A. Blair, Louis R. Ghanem, Michael S. Leibowitz, Wayne W. Hancock, Edmund K. Moon, Matthew H. Levine, Evgeniy B. Eruslanov, Douglas C. Wallace, Joseph A. Baur, Ulf H. Beier
Published 2020-12-01

Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function

by Scott L. Weiss, MD, MSCE, Kyle Bittinger, PhD, Jung-Jin Lee, PhD, Elliot S. Friedman, PhD, Lisa M. Mattei, PhD, Kathryn Graham, BS, Donglan Zhang, BS, Jeny Bush, RNC, Fran Balamuth, MD, PhD, MSCE, Francis X. McGowan, Jr, MD, Frederic D. Bushman, PhD, Robert N. Baldassano, MD, Gary D. Wu, MD, Douglas C. Wallace, PhD, Ronald G. Collman, MD
Published 2021-03-01