Correction: SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.

by Raffaella Tulino, Agnesska C Benjamin, Nelly Jolinon, Donna L Smith, Eduardo N Chini, Alisia Carnemolla, Gillian P Bates
Published 2016-01-01

SIRT1 Activity Is Linked to Its Brain Region-Specific Phosphorylation and Is Impaired in Huntington's Disease Mice.

by Raffaella Tulino, Agnesska C Benjamin, Nelly Jolinon, Donna L Smith, Eduardo N Chini, Alisia Carnemolla, Gillian P Bates
Published 2016-01-01

SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.

by Michal Mielcarek, Caroline L Benn, Sophie A Franklin, Donna L Smith, Ben Woodman, Paul A Marks, Gillian P Bates
Published 2011-01-01

Inhibition of Polyglutamine Aggregation in R6/2 HD Brain Slices—Complex Dose–Response Profiles

by Donna L. Smith, Ruben Portier, Ben Woodman, Emma Hockly, Amarbirpal Mahal, William E. Klunk, Xiao-Jiang Li, Erich Wanker, Karl D. Murray, Gillian P. Bates
Published 2001-12-01

Dysfunction of the CNS-heart axis in mouse models of Huntington's disease.

by Michal Mielcarek, Linda Inuabasi, Marie K Bondulich, Thomas Muller, Georgina F Osborne, Sophie A Franklin, Donna L Smith, Andreas Neueder, Jim Rosinski, Ivan Rattray, Andrea Protti, Gillian P Bates
Published 2014-08-01

Characterisation of immune cell function in fragment and full-length Huntington's disease mouse models

by Ulrike Träger, Ralph Andre, Anna Magnusson-Lind, James R.C. Miller, Colúm Connolly, Andreas Weiss, Stephan Grueninger, Edina Silajdžić, Donna L. Smith, Blair R. Leavitt, Gillian P. Bates, Maria Björkqvist, Sarah J. Tabrizi
Published 2015-01-01

Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.

by Maria Beconi, Omar Aziz, Kim Matthews, Lara Moumné, Catherine O'Connell, Dawn Yates, Steven Clifton, Hannah Pett, Julie Vann, Lynsey Crowley, Alan F Haughan, Donna L Smith, Ben Woodman, Gillian P Bates, Fred Brookfield, Roland W Bürli, George McAllister, Celia Dominguez, Ignacio Munoz-Sanjuan, Vahri Beaumont
Published 2012-01-01

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

by Michal Mielcarek, Christian Landles, Andreas Weiss, Amyaouch Bradaia, Tamara Seredenina, Linda Inuabasi, Georgina F Osborne, Kristian Wadel, Chrystelle Touller, Rachel Butler, Janette Robertson, Sophie A Franklin, Donna L Smith, Larry Park, Paul A Marks, Erich E Wanker, Eric N Olson, Ruth Luthi-Carter, Herman van der Putten, Vahri Beaumont, Gillian P Bates
Published 2013-11-01