Homologous Recombination Deficiency Testing for BRCA-Like Tumors: The Road to Clinical Validation

by Marjolijn M. Ladan, Dik C. van Gent, Agnes Jager
Published 2021-02-01

Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner.

by Alex N Zelensky, Mascha Schoonakker, Inger Brandsma, Marcel Tijsterman, Dik C van Gent, Jeroen Essers, Roland Kanaar
Published 2020-01-01

C-Terminal Extensions of Ku70 and Ku80 Differentially Influence DNA End Binding Properties

by Takabumi Inagawa, Thomas Wennink, Joyce H. G. Lebbink, Guido Keijzers, Bogdan I. Florea, Nicole S. Verkaik, Dik C. van Gent
Published 2020-09-01

Apalutamide Sensitizes Prostate Cancer to Ionizing Radiation via Inhibition of Non-Homologous End-Joining DNA Repair

by Wenhao Zhang, Chen-Yi Liao, Hajar Chtatou, Luca Incrocci, Dik C. van Gent, Wytske M. van Weerden, Julie Nonnekens
Published 2019-10-01

Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder.

by Nathalie van den Tempel, Kishan A T Naipal, Anja Raams, Dik C van Gent, Martine Franckena, Joost L Boormans, Roland Kanaar
Published 2018-01-01

Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells

by Stefan J. Roobol, Irene van den Bent, Wiggert A. van Cappellen, Tsion E. Abraham, Maarten W. Paul, Roland Kanaar, Adriaan B. Houtsmuller, Dik C. van Gent, Jeroen Essers
Published 2020-09-01

Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer.

by Kishan A T Naipal, Anja Raams, Serena T Bruens, Inger Brandsma, Nicole S Verkaik, Nicolaas G J Jaspers, Jan H J Hoeijmakers, Geert J L H van Leenders, Joris Pothof, Roland Kanaar, Joost Boormans, Dik C van Gent
Published 2015-01-01

The RECAP Test Rapidly and Reliably Identifies Homologous Recombination-Deficient Ovarian Carcinomas

by Lise M. van Wijk, Sylvia Vermeulen, Matty Meijers, Manuela F. van Diest, Natalja T. ter Haar, Marthe M. de Jonge, Nienke Solleveld-Westerink, Tom van Wezel, Dik C. van Gent, Judith R. Kroep, Tjalling Bosse, Katja N. Gaarenstroom, Harry Vrieling, Maaike P.G. Vreeswijk
Published 2020-09-01

HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis

by Inger Brandsma, Koichi Sato, Sari E. van Rossum-Fikkert, Nicole van Vliet, Esther Sleddens, Marcel Reuter, Hanny Odijk, Nathalie van den Tempel, Dick H.W. Dekkers, Karel Bezstarosti, Jeroen A.A. Demmers, Alex Maas, Joyce Lebbink, Claire Wyman, Jeroen Essers, Dik C. van Gent, Willy M. Baarends, Puck Knipscheer, Roland Kanaar, Alex N. Zelensky
Published 2019-06-01