Enhanced activation of memory, but not naïve, B cells in chronic hepatitis C virus-infected patients with cryoglobulinemia and advanced liver fibrosis.

by Deanna M Santer, Mang M Ma, Darren Hockman, Abdolamir Landi, D Lorne J Tyrrell, Michael Houghton
Published 2013-01-01

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells.

by Deanna M Santer, Gillian E S Minty, Dominic P Golec, Julia Lu, Julia May, Afshin Namdar, Juhi Shah, Shokrollah Elahi, David Proud, Michael Joyce, D Lorne Tyrrell, Michael Houghton
Published 2020-04-01

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.

by John Lok Man Law, Chao Chen, Jason Wong, Darren Hockman, Deanna M Santer, Sharon E Frey, Robert B Belshe, Takaji Wakita, Jens Bukh, Christopher T Jones, Charles M Rice, Sergio Abrignani, D Lorne Tyrrell, Michael Houghton
Published 2013-01-01

No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome.

by Imke Steffen, D Lorne Tyrrell, Eleanor Stein, Leilani Montalvo, Tzong-Hae Lee, Yanchen Zhou, Kai Lu, William M Switzer, Shaohua Tang, Hongwei Jia, Darren Hockman, Deanna M Santer, Michael Logan, Amir Landi, John Law, Michael Houghton, Graham Simmons
Published 2011-01-01

IL-28B is a key regulator of B- and T-cell vaccine responses against influenza.

by Adrian Egli, Deanna M Santer, Daire O'Shea, Khaled Barakat, Mohammedyaseen Syedbasha, Madeleine Vollmer, Aliyah Baluch, Rakesh Bhat, Jody Groenendyk, Michael A Joyce, Luiz F Lisboa, Brad S Thomas, Manuel Battegay, Nina Khanna, Thomas Mueller, D Lorne J Tyrrell, Michael Houghton, Atul Humar, Deepali Kumar
Published 2014-12-01