The Pekin duck programmed death ligand-2: cDNA cloning, genomic structure, molecular characterization and expression analysis

by Qingxia Yao, Karl P. Fischer, D. Lorne Tyrrell, Klaus S. Gutfreund
Published 2018-03-01

Intrinsic Viral Factors Are the Dominant Determinants of the Hepatitis C Virus Response to Interferon Alpha Treatment in Chimeric Mice.

by Ran Chen, Michelle Kobewka, William Addison, Gerald Lachance, D Lorne Tyrrell
Published 2016-01-01

Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism

by Mohammed A. Sarhan, Mohamed S. Abdel-Hakeem, Andrew L. Mason, D. Lorne Tyrrell, Michael Houghton
Published 2017-05-01

In Vitro Infection with Hepatitis B Virus Using Differentiated Human Serum Culture of Huh7.5-NTCP Cells without Requiring Dimethyl Sulfoxide

by Connie Le, Reshma Sirajee, Rineke Steenbergen, Michael A. Joyce, William R. Addison, D. Lorne Tyrrell
Published 2021-01-01

HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response.

by Michael A Joyce, Karyn M Berry-Wynne, Theodore Dos Santos, William R Addison, Nicola McFarlane, Tom Hobman, D Lorne Tyrrell
Published 2019-08-01

Postliver Transplant Allograft Reinfection with a Lamivudine-Resistant Strain of Hepatitis B Virus: Long Term Follow-up

by Eric M Yoshida, Mang M Ma, Jennifer E Davis, Karl P Fischer, Norman M Kneteman, Siegfried R Erb, D Lorne Tyrrell, Vincent G Bain
Published 1998-01-01

HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice.

by Michael A Joyce, Kathie-Anne Walters, Sue-Ellen Lamb, Mathew M Yeh, Lin-Fu Zhu, Norman Kneteman, Jason S Doyle, Michael G Katze, D Lorne Tyrrell
Published 2009-02-01

Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan

by Selena M. Sagan, Benoit Dupont, Jason Grebely, Mel Krajden, Sonya A. MacParland, Jennifer F. Raven, Sahar Saeed, Jordan J. Feld, D. Lorne Tyrrell, Joyce A. Wilson
Published 2016-01-01

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells.

by Deanna M Santer, Gillian E S Minty, Dominic P Golec, Julia Lu, Julia May, Afshin Namdar, Juhi Shah, Shokrollah Elahi, David Proud, Michael Joyce, D Lorne Tyrrell, Michael Houghton
Published 2020-04-01

Efficacy of a Peruvian Botanical Remedy (Sabell A4+) for Treating Liver Disease and Protecting Gastric Mucosal Integrity

by Mark G. Swain, John L. Wallace, D. Lorne Tyrrell, José Cabanillas, Steven K. H. Aung, Hongqun Liu, Lindsay Finnie-Carvalho, Grishma Shrestha, Hugh A. Semple, Francis H. Y. Green
Published 2019-01-01

Host-specific response to HCV infection in the chimeric SCID-beige/Alb-uPA mouse model: role of the innate antiviral immune response.

by Kathie-Anne Walters, Michael A Joyce, Jill C Thompson, Maria W Smith, Matthew M Yeh, Sean Proll, Lin-Fu Zhu, T J Gao, Norman M Kneteman, D Lorne Tyrrell, Michael G Katze
Published 2006-06-01

A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans.

by John Lok Man Law, Chao Chen, Jason Wong, Darren Hockman, Deanna M Santer, Sharon E Frey, Robert B Belshe, Takaji Wakita, Jens Bukh, Christopher T Jones, Charles M Rice, Sergio Abrignani, D Lorne Tyrrell, Michael Houghton
Published 2013-01-01

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

by Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Published 2020-10-01

In Vitro Hepatitis C Virus Infection and Hepatic Choline Metabolism

by Kaelan Gobeil Odai, Conor O’Dwyer, Rineke Steenbergen, Tyler A. Shaw, Tyler M. Renner, Peyman Ghorbani, Mojgan Rezaaifar, Shauna Han, Marc-André Langlois, Angela M. Crawley, Rodney S. Russell, John P. Pezacki, D. Lorne Tyrrell, Morgan D. Fullerton
Published 2020-01-01

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

by Wayne Vuong, Muhammad Bashir Khan, Conrad Fischer, Elena Arutyunova, Tess Lamer, Justin Shields, Holly A. Saffran, Ryan T. McKay, Marco J. van Belkum, Michael A. Joyce, Howard S. Young, D. Lorne Tyrrell, John C. Vederas, M. Joanne Lemieux
Published 2020-08-01

No evidence for XMRV nucleic acids, infectious virus or anti-XMRV antibodies in Canadian patients with chronic fatigue syndrome.

by Imke Steffen, D Lorne Tyrrell, Eleanor Stein, Leilani Montalvo, Tzong-Hae Lee, Yanchen Zhou, Kai Lu, William M Switzer, Shaohua Tang, Hongwei Jia, Darren Hockman, Deanna M Santer, Michael Logan, Amir Landi, John Law, Michael Houghton, Graham Simmons
Published 2011-01-01

The 3rd Canadian Symposium on Hepatitis C Virus: Expanding Care in the Interferon-Free Era

by Sonya A MacParland, Marc Bilodeau, Jason Grebely, Julie Bruneau, Curtis Cooper, Marina Klein, Selena M Sagan, Norma Choucha, Louise Balfour, Frank Bialystok, Mel Krajden, Jennifer Raven, Eve Roberts, Rodney Russell, Michael Houghton, D Lorne Tyrrell, Jordan J Feld
Published 2014-01-01

IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes

by Adrian Egli, Jyotshna Mandal, Desiree M. Schumann, Michael Roth, Brad Thomas, D. Lorne Tyrrell, Francesco Blasi, Kostantinos Kostikas, Wim Boersma, Branislava Milenkovic, Alicia Lacoma, Katharina Rentsch, Gernot G. U. Rohde, Renaud Louis, Joachim G. Aerts, Tobias Welte, Antoni Torres, Michael Tamm, Daiana Stolz
Published 2018-03-01

The Second Canadian Symposium on Hepatitis C Virus: A Call to Action

by Jason Grebely, Marc Bilodeau, Jordan J Feld, Julie Bruneau, Benedikt Fischer, Jennifer F Raven, Eve Roberts, Norma Choucha, Rob P Myers, Selena M Sagan, Joyce A Wilson, Frank Bialystok, D Lorne Tyrrell, Michael Houghton, Mel Krajden, on behalf of the National CIHR Research Training Program in Hepatitis C
Published 2013-01-01

Antibodies to neutralising epitopes synergistically block the interaction of the receptor‐binding domain of SARS‐CoV‐2 to ACE 2

by Manisha Pandey, Victoria Ozberk, Sharareh Eskandari, Ahmed O Shalash, Michael A Joyce, Holly A Saffran, Christopher J Day, Ailin Lepletier, Belinda L Spillings, Jamie‐Lee Mills, Ainslie Calcutt, Fan Fan, James T Williams, Danielle I Stanisic, Laetitia Hattingh, John Gerrard, Mariusz Skwarczynski, Johnson Mak, Michael P Jennings, Istvan Toth, D Lorne Tyrrell, Michael F Good
Published 2021-01-01