Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1STEM Mouse

by Francois E. Mercier, David B. Sykes, David T. Scadden
Published 2016-06-01

Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities?

by Allison K Scherer, Alex Hopke, David B Sykes, Daniel Irimia, Michael K Mansour
Published 2021-07-01

SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst

by Giang T Nguyen, Lamyaa Shaban, Matthias Mack, Kenneth D Swanson, Stephen C Bunnell, David B Sykes, Joan Mecsas
Published 2020-04-01

Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation

by Giang T. Nguyen, Shuying Xu, Walter Adams, John M. Leong, Stephen C. Bunnell, Michael K. Mansour, David B. Sykes, Joan Mecsas
Published 2021-08-01

An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections.

by J Scott Fites, Michael Gui, John F Kernien, Paige Negoro, Zeina Dagher, David B Sykes, Jeniel E Nett, Michael K Mansour, Bruce S Klein
Published 2018-05-01

Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages

by Zeina Dagher, Shuying Xu, Paige E. Negoro, Nida S. Khan, Nida S. Khan, Michael B. Feldman, Jennifer L. Reedy, Jenny M. Tam, David B. Sykes, Michael K. Mansour
Published 2018-05-01

RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability

by Edwin Chen, Jong Sook Ahn, David B. Sykes, Lawrence J. Breyfogle, Anna L. Godfrey, Jyoti Nangalia, Amy Ko, Daniel J. DeAngelo, Anthony R. Green, Ann Mullally
Published 2015-12-01

Biguanides enhance antifungal activity against Candida glabrata

by Shuying Xu, Marianela Feliu, Allison K. Lord, Daniel P. Lukason, Paige E. Negoro, Nida S. Khan, Zeina Dagher, Michael B. Feldman, Jennifer L. Reedy, Samantha N. Steiger, Jenny M. Tam, Alexander A. Soukas, David B. Sykes, Michael K. Mansour
Published 2018-12-01

Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses

by Siang-Boon Koh, Brian N. Dontchos, Veerle Bossuyt, Christine Edmonds, Simona Cristea, Nsan Melkonjan, Lindsey Mortensen, Annie Ma, Kassidy Beyerlin, Elyssa Denault, Elizabeth Niehoff, Taghreed Hirz, David B. Sykes, Franziska Michor, Michelle Specht, Constance Lehman, Leif W. Ellisen, Laura M. Spring
Published 2021-09-01

Chromatin accessibility promotes hematopoietic and leukemia stem cell activity

by Lucia Cabal-Hierro, Peter van Galen, Miguel A. Prado, Kelly J. Higby, Katsuhiro Togami, Cody T. Mowery, Joao A. Paulo, Yingtian Xie, Paloma Cejas, Takashi Furusawa, Michael Bustin, Henry W. Long, David B. Sykes, Steven P. Gygi, Daniel Finley, Bradley E. Bernstein, Andrew A. Lane
Published 2020-03-01

Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species

by Paige E. Negoro, Shuying Xu, Zeina Dagher, Alex Hopke, Jennifer L. Reedy, Michael B. Feldman, Nida S. Khan, Adam L. Viens, Natalie J. Alexander, Natalie J. Atallah, Allison K. Scherer, Richard A. Dutko, Jane Jeffery, John F. Kernien, J. Scott Fites, Jeniel E. Nett, Bruce S. Klein, Jatin M. Vyas, Daniel Irimia, David B. Sykes, Michael K. Mansour
Published 2020-05-01

Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia

by Barry M. Zee, Kamrine E. Poels, Cong-Hui Yao, Kimihito C. Kawabata, Gongwei Wu, Cihangir Duy, William D. Jacobus, Elizabeth Senior, Jennifer E. Endress, Ashwini Jambhekar, Scott B. Lovitch, Jiexian Ma, Abhinav Dhall, Isaac S. Harris, M. Andres Blanco, David B. Sykes, Jonathan D. Licht, David M. Weinstock, Ari Melnick, Marcia C. Haigis, Franziska Michor, Yang Shi
Published 2021-06-01

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors

by Shrikanta Chattopadhyay, Alison L. Stewart, Siddhartha Mukherjee, Cherrie Huang, Kimberly A. Hartwell, Peter G. Miller, Radhika Subramanian, Leigh C. Carmody, Rushdia Z. Yusuf, David B. Sykes, Joshiawa Paulk, Amedeo Vetere, Sonia Vallet, Loredana Santo, Diana D. Cirstea, Teru Hideshima, Vlado Dančík, Max M. Majireck, Mahmud M. Hussain, Shambhavi Singh, Ryan Quiroz, Jonathan Iaconelli, Rakesh Karmacharya, Nicola J. Tolliday, Paul A. Clemons, Malcolm A.S. Moore, Andrew M. Stern, Alykhan F. Shamji, Benjamin L. Ebert, Todd R. Golub, Noopur S. Raje, David T. Scadden, Stuart L. Schreiber
Published 2015-02-01