Highly Drug-Resistant HIV‑1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues

by Johnson Agniswamy, Daniel W. Kneller, Rowan Brothers, Yuan-Fang Wang, Robert W. Harrison, Irene T. Weber
Published 2019-05-01

Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL Mpro: insights into enzyme mechanism and drug design

by Daniel W. Kneller, Gwyndalyn Phillips, Hugh M. O'Neill, Kemin Tan, Andrzej Joachimiak, Leighton Coates, Andrey Kovalevsky
Published 2020-11-01

Structural plasticity of SARS-CoV-2 3CL Mpro active site cavity revealed by room temperature X-ray crystallography

by Daniel W. Kneller, Gwyndalyn Phillips, Hugh M. O’Neill, Robert Jedrzejczak, Lucy Stols, Paul Langan, Andrzej Joachimiak, Leighton Coates, Andrey Kovalevsky
Published 2020-06-01