Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes

by Kristina Hopfensperger, Daniel Sauter
Published 2020-05-01

Evolutionary conflicts and adverse effects of antiviral factors

by Daniel Sauter, Frank Kirchhoff
Published 2021-01-01

Furin‐mediated protein processing in infectious diseases and cancer

by Elisabeth Braun, Daniel Sauter
Published 2019-01-01

Vpu-Mediated Counteraction of Tetherin Is a Major Determinant of HIV-1 Interferon Resistance

by Dorota Kmiec, Shilpa S. Iyer, Christina M. Sturzel, Daniel Sauter, Beatrice H. Hahn, Frank Kirchhoff
Published 2016-08-01

Sarbecovirus ORF6 proteins hamper induction of interferon signaling

by Izumi Kimura, Yoriyuki Konno, Keiya Uriu, Kristina Hopfensperger, Daniel Sauter, So Nakagawa, Kei Sato
Published 2021-03-01

Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3

by Santiago Manrique, Daniel Sauter, Florian A. Horenkamp, Sebastian Lülf, Hangxing Yu, Dominik Hotter, Kanchan Anand, Frank Kirchhoff, Matthias Geyer
Published 2017-09-01

SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant

by Yoriyuki Konno, Izumi Kimura, Keiya Uriu, Masaya Fukushi, Takashi Irie, Yoshio Koyanagi, Daniel Sauter, Robert J. Gifford, So Nakagawa, Kei Sato
Published 2020-09-01

A Naturally Occurring rev1-vpu Fusion Gene Does Not Confer a Fitness Advantage to HIV-1.

by Simon M Langer, Kristina Hopfensperger, Shilpa S Iyer, Edward F Kreider, Gerald H Learn, Lan-Hui Lee, Beatrice H Hahn, Daniel Sauter
Published 2015-01-01

Targeting of CXCR4 by the Naturally Occurring CXCR4 Antagonist EPI-X4 in Waldenström’s Macroglobulinemia

by Lisa Marie Kaiser, Mirja Harms, Daniel Sauter, Vijay P. S. Rawat, Mirco Glitscher, Eberhard Hildt, Daniel Tews, Zachary Hunter, Jan Münch, Christian Buske
Published 2021-02-01

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation.

by Dominik Hotter, Teresa Krabbe, Elisabeth Reith, Ali Gawanbacht, Nadia Rahm, Ahidjo Ayouba, Benoît Van Driessche, Carine Van Lint, Martine Peeters, Frank Kirchhoff, Daniel Sauter
Published 2017-08-01

Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2

by Kristina Hopfensperger, Jonathan Richard, Christina M. Stürzel, Frederic Bibollet-Ruche, Richard Apps, Marie Leoz, Jean-Christophe Plantier, Beatrice H. Hahn, Andrés Finzi, Frank Kirchhoff, Daniel Sauter
Published 2020-07-01

An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins

by Matteo Bosso, Christina M. Stürzel, Dorota Kmiec, Smitha Srinivasachar Badarinarayan, Elisabeth Braun, Jumpei Ito, Kei Sato, Beatrice H. Hahn, Konstantin M.J. Sparrer, Daniel Sauter, Frank Kirchhoff
Published 2021-09-01

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.

by Jingyan Chen, Nadine Tibroni, Daniel Sauter, Johanna Galaski, Toshiyuki Miura, Galit Alter, Birthe Mueller, Claudia Haller, Bruce D Walker, Frank Kirchhoff, Zabrina L Brumme, Takamasa Ueno, Oliver T Fackler
Published 2015-01-01

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

by Jolien Vermeire, Ferdinand Roesch, Daniel Sauter, Réjane Rua, Dominik Hotter, Anouk Van Nuffel, Hanne Vanderstraeten, Evelien Naessens, Veronica Iannucci, Alessia Landi, Wojciech Witkowski, Ann Baeyens, Frank Kirchhoff, Bruno Verhasselt
Published 2016-10-01

CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

by Dorota Kmiec, Rayhane Nchioua, Scott Sherrill-Mix, Christina M. Stürzel, Elena Heusinger, Elisabeth Braun, Marcos V. P. Gondim, Dominik Hotter, Konstantin M. J. Sparrer, Beatrice H. Hahn, Daniel Sauter, Frank Kirchhoff
Published 2020-01-01

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

by Daniel Sauter, Dominik Hotter, Benoît Van Driessche, Christina M. Stürzel, Silvia F. Kluge, Steffen Wildum, Hangxing Yu, Bernd Baumann, Thomas Wirth, Jean-Christophe Plantier, Marie Leoz, Beatrice H. Hahn, Carine Van Lint, Frank Kirchhoff
Published 2015-02-01

A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx

by Christine D. Landsberg, Dominik A. Megger, Dominik A. Megger, Dominik Hotter, Meike U. Rückborn, Mareike Eilbrecht, Jassin Rashidi-Alavijeh, Sebastian Howe, Stefan Heinrichs, Daniel Sauter, Barbara Sitek, Vu Thuy Khanh Le-Trilling, Mirko Trilling
Published 2018-12-01

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

by Simon Langer, Christian Hammer, Kristina Hopfensperger, Lukas Klein, Dominik Hotter, Paul D De Jesus, Kristina M Herbert, Lars Pache, Nikaïa Smith, Johannes A van der Merwe, Sumit K Chanda, Jacques Fellay, Frank Kirchhoff, Daniel Sauter
Published 2019-02-01

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.

by Dorota Kmiec, Bengisu Akbil, Swetha Ananth, Dominik Hotter, Konstantin M J Sparrer, Christina M Stürzel, Birthe Trautz, Ahidjo Ayouba, Martine Peeters, Zhong Yao, Igor Stagljar, Vânia Passos, Thomas Zillinger, Christine Goffinet, Daniel Sauter, Oliver T Fackler, Frank Kirchhoff
Published 2018-08-01

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.

by Daniel Sauter, Daniel Unterweger, Michael Vogl, Shariq M Usmani, Anke Heigele, Silvia F Kluge, Elisabeth Hermkes, Markus Moll, Edward Barker, Martine Peeters, Gerald H Learn, Frederic Bibollet-Ruche, Joëlle V Fritz, Oliver T Fackler, Beatrice H Hahn, Frank Kirchhoff
Published 2012-12-01