How Do We “Validate” a QSP Model?

by Daniel C. Kirouac
Published 2018-09-01

HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B.

by Daniel C Kirouac, Jinyan Du, Johanna Lahdenranta, Matthew D Onsum, Ulrik B Nielsen, Birgit Schoeberl, Charlotte F McDonagh
Published 2016-04-01

Virtual clinical trial simulations for a novel KRASG12C inhibitor (ASP2453) in non‐small cell lung cancer

by Hiroyuki Sayama, Diana Marcantonio, Takeyuki Nagashima, Masashi Shimazaki, Tsuyoshi Minematsu, Joshua F Apgar, John M. Burke, Lucia Wille, Yasuhisa Nagasaka, Daniel C. Kirouac
Published 2021-08-01

Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

by Daniel C. Kirouac, Gabriele Schaefer, Jocelyn Chan, Mark Merchant, Christine Orr, Shih-Min A. Huang, John Moffat, Lichuan Liu, Kapil Gadkar, Saroja Ramanujan
Published 2017-06-01