Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

by Daniel C. Kirouac, Gabriele Schaefer, Jocelyn Chan, Mark Merchant, Christine Orr, Shih-Min A. Huang, John Moffat, Lichuan Liu, Kapil Gadkar, Saroja Ramanujan
Published 2017-06-01

SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.

by Jesse E Hanson, Hank La, Emile Plise, Yung-Hsiang Chen, Xiao Ding, Taleen Hanania, Emily V Sabath, Vadim Alexandrov, Dani Brunner, Emer Leahy, Pascal Steiner, Lichuan Liu, Kimberly Scearce-Levie, Qiang Zhou
Published 2013-01-01

Recommendations for the Design of Clinical Drug–Drug Interaction Studies With Itraconazole Using a Mechanistic Physiologically‐Based Pharmacokinetic Model

by Yuan Chen, Tamara D. Cabalu, Ernesto Callegari, Heidi Einolf, Lichuan Liu, Neil Parrott, Sheila Annie Peters, Edgar Schuck, Pradeep Sharma, Helen Tracey, Vijay V. Upreti, Ming Zheng, Andy Z.X. Zhu, Stephen D. Hall
Published 2019-09-01