Reverse evolution leads to genotypic incompatibility despite functional and active site convergence

by Miriam Kaltenbach, Colin J Jackson, Eleanor C Campbell, Florian Hollfelder, Nobuhiko Tokuriki
Published 2015-08-01

Classification and substrate head-group specificity of membrane fatty acid desaturases

by Dongdi Li, Ruth Moorman, Thomas Vanhercke, James Petrie, Surinder Singh, Colin J. Jackson
Published 2016-01-01

Geographic Linkage and Variation in Cryptosporidium hominis

by Rachel M. Chalmers, Stephen J. Hadfield, Colin J. Jackson, Kristin Elwin, Lihua Xiao, Paul Hunter
Published 2008-03-01

A 5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis.

by Tatheer Naqvi, Andrew C Warden, Nigel French, Elena Sugrue, Paul D Carr, Colin J Jackson, Colin Scott
Published 2014-01-01

Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera.

by Sunita Biswas, Robyn J Russell, Colin J Jackson, Maria Vidovic, Olga Ganeshina, John G Oakeshott, Charles Claudianos
Published 2008-01-01

Intramolecular epistasis and the evolution of a new enzymatic function.

by Sajid Noor, Matthew C Taylor, Robyn J Russell, Lars S Jermiin, Colin J Jackson, John G Oakeshott, Colin Scott
Published 2012-01-01

Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers.

by Pooja Sharma, Rinku Pandey, Kirti Kumari, Gunjan Pandey, Colin J Jackson, Robyn J Russell, John G Oakeshott, Rup Lal
Published 2011-01-01

Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

by Joe A. Kaczmarski, Mithun C. Mahawaththa, Akiva Feintuch, Ben E. Clifton, Luke A. Adams, Daniella Goldfarb, Gottfried Otting, Colin J. Jackson
Published 2020-11-01

Structural and functional characterization of a putative de novo gene in Drosophila

by Andreas Lange, Prajal H. Patel, Brennen Heames, Adam M. Damry, Thorsten Saenger, Colin J. Jackson, Geoffrey D. Findlay, Erich Bornberg-Bauer
Published 2021-03-01

Cofactor F₄₂₀-Dependent Enzymes: An Under-Explored Resource for Asymmetric Redox Biocatalysis

by Mihir V. Shah, James Antoney, Suk Woo Kang, Andrew C. Warden, Carol J. Hartley, Hadi Nazem-Bokaee, Colin J. Jackson, Colin Scott
Published 2019-10-01

Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes

by Florian Baier, Nansook Hong, Gloria Yang, Anna Pabis, Charlotte M Miton, Alexandre Barrozo, Paul D Carr, Shina CL Kamerlin, Colin J Jackson, Nobuhiko Tokuriki
Published 2019-02-01

Avid binding by B cells to the Plasmodium circumsporozoite protein repeat suppresses responses to protective subdominant epitopes

by Deepyan Chatterjee, Fiona J. Lewis, Henry J. Sutton, Joe A. Kaczmarski, Xin Gao, Yeping Cai, Hayley A. McNamara, Colin J. Jackson, Ian A. Cockburn
Published 2021-04-01

Local Efficacy of Glutamate Uptake Decreases with Synapse Size

by Michel K. Herde, Kirsten Bohmbach, Cátia Domingos, Natascha Vana, Joanna A. Komorowska-Müller, Stefan Passlick, Inna Schwarz, Colin J. Jackson, Dirk Dietrich, Martin K. Schwarz, Christian Henneberger
Published 2020-09-01

Cofactor Tail Length Modulates Catalysis of Bacterial F420-Dependent Oxidoreductases

by Blair Ney, Blair Ney, Carlo R. Carere, Richard Sparling, Richard Sparling, Thanavit Jirapanjawat, Matthew B. Stott, Colin J. Jackson, John G. Oakeshott, Andrew C. Warden, Chris Greening, Chris Greening
Published 2017-09-01

A revised biosynthetic pathway for the cofactor F420 in prokaryotes

by Ghader Bashiri, James Antoney, Ehab N. M. Jirgis, Mihir V. Shah, Blair Ney, Janine Copp, Stephanie M. Stuteley, Sreevalsan Sreebhavan, Brian Palmer, Martin Middleditch, Nobuhiko Tokuriki, Chris Greening, Colin Scott, Edward N. Baker, Colin J. Jackson
Published 2019-04-01

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.

by Camilla R Fisher, Henry J Sutton, Joe A Kaczmarski, Hayley A McNamara, Ben Clifton, Joshua Mitchell, Yeping Cai, Johanna N Dups, Nicholas J D'Arcy, Mandeep Singh, Aaron Chuah, Thomas S Peat, Colin J Jackson, Ian A Cockburn
Published 2017-07-01

The evolution of multiple active site configurations in a designed enzyme

by Nan-Sook Hong, Dušan Petrović, Richmond Lee, Ganna Gryn’ova, Miha Purg, Jake Saunders, Paul Bauer, Paul D. Carr, Ching-Yeh Lin, Peter D. Mabbitt, William Zhang, Timothy Altamore, Chris Easton, Michelle L. Coote, Shina C. L. Kamerlin, Colin J. Jackson
Published 2018-09-01

Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

by Thierry Izoré, Y. T. Candace Ho, Joe A. Kaczmarski, Athina Gavriilidou, Ka Ho Chow, David L. Steer, Robert J. A. Goode, Ralf B. Schittenhelm, Julien Tailhades, Manuela Tosin, Gregory L. Challis, Elizabeth H. Krenske, Nadine Ziemert, Colin J. Jackson, Max J. Cryle
Published 2021-05-01

Mycobacterial F420H2-Dependent Reductases Promiscuously Reduce Diverse Compounds through a Common Mechanism

by Chris Greening, Chris Greening, Thanavit Jirapanjawat, Thanavit Jirapanjawat, Thanavit Jirapanjawat, Shahana Afroze, Shahana Afroze, Blair Ney, Blair Ney, Blair Ney, Colin Scott, Gunjan Pandey, Brendon M. Lee, Brendon M. Lee, Robyn J. Russell, Colin J. Jackson, John G. Oakeshott, Matthew C. Taylor, Andrew C. Warden
Published 2017-05-01

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

by Anja Greule, Thierry Izoré, Dumitrita Iftime, Julien Tailhades, Melanie Schoppet, Yongwei Zhao, Madeleine Peschke, Iftekhar Ahmed, Andreas Kulik, Martina Adamek, Robert J. A. Goode, Ralf B. Schittenhelm, Joe A. Kaczmarski, Colin J. Jackson, Nadine Ziemert, Elizabeth H. Krenske, James J. De Voss, Evi Stegmann, Max J. Cryle
Published 2019-06-01