Article Chromatin DNA DNA Methylation DNA binding protein DNA methylation DNA-Binding Proteins Humans Intrinsically disordered protein (IDP) Methyl-CpG-Binding Protein 2 Methyl-CpG-binding protein 2 (MeCP2) Mutation Protein Binding Protein Domains Protein Stability Protein Structure, Secondary Protein stability and interactions Transcription Factors amino terminal sequence binding site biophysics carboxy terminal sequence chemistry chromatin controlled study human intrinsically disordered protein metabolism methyl CpG binding protein 2 mutation