Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

by Zaloumis Sophie, Humberstone Andrew, Charman Susan A, Price Ric N, Moehrle Joerg, Gamo-Benito Javier, McCaw James, Jamsen Kris M, Smith Katherine, Simpson Julie A
Published 2012-08-01

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

by Shackleford David M, Roncal Norma, Norval Suzanne, Read Kevin D, Moon Jay, McCalmont William, Mannila Anne, Lanteri Charlotte, Kozar Michael, Gerena Lucia, Gardner Sean, Caridha Diana, Bhonsle Jayendra, Bathurst Ian, Milner Erin, Dow Geoffrey S, Sousa Jason, Steuten Jessica, White Karen L, Zeng Qiang, Charman Susan A
Published 2011-06-01