The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.

by Xitiz Chamling, Seongjin Seo, Charles C Searby, Gunhee Kim, Diane C Slusarski, Val C Sheffield
Published 2014-02-01

Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments

by Jeffrey M. Stolwijk, Kelly C. Falls-Hubert, Charles C. Searby, Brett A. Wagner, Garry R. Buettner
Published 2020-05-01

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.

by Seongjin Seo, Qihong Zhang, Kevin Bugge, David K Breslow, Charles C Searby, Maxence V Nachury, Val C Sheffield
Published 2011-11-01

Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin

by Ramesh B. Kasetti, Prabhavathi Maddineni, Charles Kiehlbauch, Shruti Patil, Charles C. Searby, Beth Levine, Val C. Sheffield, Gulab S. Zode
Published 2021-03-01

Nuclear/cytoplasmic transport defects in BBS6 underlie congenital heart disease through perturbation of a chromatin remodeling protein.

by Charles Anthony Scott, Autumn N Marsden, Michael R Rebagliati, Qihong Zhang, Xitiz Chamling, Charles C Searby, Lisa M Baye, Val C Sheffield, Diane C Slusarski
Published 2017-07-01

BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.

by Ying Hsu, Janelle E Garrison, Gunhee Kim, Addison R Schmitz, Charles C Searby, Qihong Zhang, Poppy Datta, Darryl Y Nishimura, Seongjin Seo, Val C Sheffield
Published 2017-10-01

ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

by Ramesh B. Kasetti, Pinkal D. Patel, Prabhavathi Maddineni, Shruti Patil, Charles Kiehlbauch, J. Cameron Millar, Charles C. Searby, VijayKrishna Raghunathan, Val C. Sheffield, Gulab S. Zode
Published 2020-11-01

Identification and functional analysis of the vision-specific BBS3 (ARL6) long isoform.

by Pamela R Pretorius, Lisa M Baye, Darryl Y Nishimura, Charles C Searby, Kevin Bugge, Baoli Yang, Robert F Mullins, Edwin M Stone, Val C Sheffield, Diane C Slusarski
Published 2010-03-01