Multiple biomarkers predict disease severity, progression and mortality in COPD

by Rachel L. Zemans, Sean Jacobson, Jason Keene, Katerina Kechris, Bruce E. Miller, Ruth Tal-Singer, Russell P. Bowler
Published 2017-06-01

Three-class differential diagnosis among Alzheimer disease, Frontotemporal dementia and controls

by Pradeep Redddy eRaamana, Howard eRosen, Bruce eMiller, Michael W Weiner, Lei eWang, Mirza Faisal eBeg
Published 2014-05-01

CXCR2 antagonist for patients with chronic obstructive pulmonary disease with chronic mucus hypersecretion: a phase 2b trial

by Aili L. Lazaar, Bruce E. Miller, Alison C. Donald, Thomas Keeley, Claire Ambery, John Russell, Henrik Watz, Ruth Tal-Singer, for 205724 Investigators
Published 2020-06-01

Bacteria and sputum inflammatory cell counts; a COPD cohort analysis

by Augusta S. Beech, Simon Lea, Umme Kolsum, Zhang Wang, Bruce E. Miller, Gavin C. Donaldson, Jadwiga A. Wedzicha, Christopher E. Brightling, Dave Singh
Published 2020-11-01

CXCL-8-dependent and -independent neutrophil activation in COPD: experiences from a pilot study of the CXCR2 antagonist danirixin

by Holly R. Keir, Hollian Richardson, Christina Fillmore, Amelia Shoemark, Aili L. Lazaar, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers, Divya Mohan
Published 2020-11-01

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD

by Mike Lonergan, Alison J. Dicker, Megan L. Crichton, Holly R. Keir, Melissa K. Van Dyke, Hana Mullerova, Bruce E. Miller, Ruth Tal-Singer, James D. Chalmers
Published 2020-07-01

Endotrophin, an extracellular hormone, in combination with neoepitope markers of von Willebrand factor improves prediction of mortality in the ECLIPSE COPD cohort

by Sarah R. Rønnow, Lasse L. Langholm, Morten A. Karsdal, Tina Manon-Jensen, Ruth Tal-Singer, Bruce E. Miller, Jørgen Vestbo, Diana J. Leeming, Jannie M. B. Sand
Published 2020-07-01

Type IV collagen turnover is predictive of mortality in COPD: a comparison to fibrinogen in a prospective analysis of the ECLIPSE cohort

by Sarah Rank Rønnow, Jannie Marie Bülow Sand, Lasse Løcke Langholm, Tina Manon-Jensen, Morten Asser Karsdal, Ruth Tal-Singer, Bruce E. Miller, Jørgen Vestbo, Diana Julie Leeming
Published 2019-04-01

Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis

by Rosa Faner, Jarrett D. Morrow, Sandra Casas-Recasens, Suzanne M. Cloonan, Guillaume Noell, Alejandra López-Giraldo, Ruth Tal-Singer, Bruce E. Miller, Edwin K. Silverman, Alvar Agustí, Craig P. Hersh
Published 2019-01-01

The Effect of Statins on Blood Gene Expression in COPD.

by Ma'en Obeidat, Nick Fishbane, Yunlong Nie, Virginia Chen, Zsuzsanna Hollander, Scott J Tebbutt, Yohan Bossé, Raymond T Ng, Bruce E Miller, Bruce McManus, Stephen Rennard, Peter D Paré, Don D Sin
Published 2015-01-01

Biomarkers of collagen turnover are related to annual change in FEV1 in patients with chronic obstructive pulmonary disease within the ECLIPSE study

by Diana J. Leeming, Inger Byrjalsen, Jannie M. B. Sand, Asger R. Bihlet, Peter Lange, The Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) study investigators, Ruth Thal-Singer, Bruce E. Miller, Morten A. Karsdal, Jørgen Vestbo
Published 2017-12-01

Investigation of the Clinical, Radiological and Biological Factors Associated with Disease Progression, Phenotypes and Endotypes of COPD in China (COMPASS): study design, protocol...

by Zhenyu Liang, Nanshan Zhong, Rongchang Chen, Qianli Ma, Yongchang Sun, Fuqiang Wen, Ruth Tal-Singer, Bruce E. Miller, Julie Yates, Jie Song, Chris Compton, Beulah Ji, Li Wu, Yang Yang, Paul Jones, Jinping Zheng
Published 2021-09-01

InforMing the PAthway of COPD Treatment (IMPACT) trial: fibrinogen levels predict risk of moderate or severe exacerbations

by Dave Singh, Gerard J. Criner, Mark T. Dransfield, David M. G. Halpin, MeiLan K. Han, Peter Lange, Sally Lettis, David A. Lipson, David Mannino, Neil Martin, Fernando J. Martinez, Bruce E. Miller, Robert Wise, Chang-Qing Zhu, David Lomas
Published 2021-04-01

Network-based analysis reveals novel gene signatures in peripheral blood of patients with chronic obstructive pulmonary disease

by Ma’en Obeidat, Yunlong Nie, Virginia Chen, Casey P. Shannon, Anand Kumar Andiappan, Bernett Lee, Olaf Rotzschke, Peter J. Castaldi, Craig P. Hersh, Nick Fishbane, Raymond T. Ng, Bruce McManus, Bruce E. Miller, Stephen Rennard, Peter D. Paré, Don D. Sin
Published 2017-04-01

The sputum microbiome is distinct between COPD and health, independent of smoking history

by Koirobi Haldar, Leena George, Zhang Wang, Vijay Mistry, Mohammadali Yavari Ramsheh, Robert C. Free, Catherine John, Nicola F. Reeve, Bruce E. Miller, Ruth Tal-Singer, Adam J. Webb, Anthony J. Brookes, Martin D. Tobin, Dave Singh, Gavin C. Donaldson, Jadwiga A. Wedzicha, James R. Brown, Michael R. Barer, Christopher E. Brightling
Published 2020-07-01

Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.

by Alvar Agustí, Lisa D Edwards, Stephen I Rennard, William MacNee, Ruth Tal-Singer, Bruce E Miller, Jørgen Vestbo, David A Lomas, Peter M A Calverley, Emiel Wouters, Courtney Crim, Julie C Yates, Edwin K Silverman, Harvey O Coxson, Per Bakke, Ruth J Mayer, Bartolome Celli, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Published 2012-01-01

Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD

by Katherine A. Pratte, Jeffrey L. Curtis, Katerina Kechris, David Couper, Michael H. Cho, Edwin K. Silverman, Dawn L. DeMeo, Frank C. Sciurba, Yingze Zhang, Victor E. Ortega, Wanda K. O’Neal, Lucas A. Gillenwater, David A. Lynch, Eric A. Hoffman, John D. Newell, Alejandro P. Comellas, Peter J. Castaldi, Bruce E. Miller, Simon D. Pouwels, Nick H. T. ten Hacken, Rainer Bischoff, Frank Klont, Prescott G. Woodruff, Robert Paine, R. Graham Barr, John Hoidal, Claire M. Doerschuk, Jean-Paul Charbonnier, Ruby Sung, Nicholas Locantore, John G. Yonchuk, Sean Jacobson, Ruth Tal-singer, Debbie Merrill, Russell P. Bowler
Published 2021-04-01