Double Intramolecular Transacetalization of Polyhydroxy Acetals: Synthesis of Conformationally-Restricted 1,3-Dioxanes with Axially-Oriented Phenyl Moiety

by Samuel Asare-Nkansah, Bernhard Wünsch
Published 2016-11-01

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

by Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch
Published 2016-05-01

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective...

by Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch
Published 2016-05-01

Rigid Scaffolds: Synthesis of 2,6‐Bridged Piperazines with Functional Groups in all three Bridges

by Donglin Gao, Dr. Christian Penno, Prof. Bernhard Wünsch
Published 2020-08-01

EMC Component Modeling and System-Level Simulations of Power Converters: AC Motor Drives

by Bernhard Wunsch, Stanislav Skibin, Ville Forsström, Ivica Stevanovic
Published 2021-03-01

1st Joint European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015)

by Marc Le Borgne, Samer Haidar, Olivier Duval, Bernhard Wünsch, Joachim Jose
Published 2015-12-01

Quantitative Structure–Activity Relationships of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents

by Friederike M. Wunsch, Bernhard Wünsch, Freddy A. Bernal, Thomas J. Schmidt
Published 2021-08-01

Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity

by Héctor Torres-Gómez, Constantin Daniliuc, Dirk Schepmann, Erik Laurini, Sabrina Pricl, Bernhard Wünsch
Published 2021-05-01

Deconstruction – Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold

by Nadine Ritter, Marvin Korff, Alexander Markus, Dirk Schepmann, Guiscard Seebohm, Julian A. Schreiber, Bernhard Wünsch
Published 2021-03-01

Targeting Kca3.1 Channels in Cancer

by Luca Matteo Todesca, Sarah Maskri, Kathrin Brömmel, Insa Thale, Bernhard Wünsch, Oliver Koch, Albrecht Schwab
Published 2021-05-01

A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors

by Alexander Schnitzler, Andreas Gratz, Andre Bollacke, Michael Weyrich, Uwe Kuckländer, Bernhard Wünsch, Claudia Götz, Karsten Niefind, Joachim Jose
Published 2018-02-01

Can Unlikely Neanderthal Chloride Channel CLC-2 Gene Variants Provide Insights in Modern Human Infertility?

by Elena Jeworutzki, Frank Tüttelmann, Ina Rothenberg, Michael Pusch, Julian A. Schreiber, Sabine Kliesch, Bernhard Wünsch, Nathalie Strutz-Seebohm, Guiscard Seebohm
Published 2021-06-01

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain

by Katharina Holl, Dirk Schepmann, Steffen Fischer, Friedrich-Alexander Ludwig, Achim Hiller, Cornelius K. Donat, Winnie Deuther-Conrad, Peter Brust, Bernhard Wünsch
Published 2014-01-01

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant ¹⁸F-Labelled σ₂ Receptor Ligand

by Rareş-Petru Moldovan, Daniel Gündel, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Steffen Fischer, Magali Toussaint, Dirk Schepmann, Bernhard Wünsch, Peter Brust, Winnie Deuther-Conrad
Published 2021-05-01

Sigma-1 Receptor Positron Emission Tomography: A New Molecular Imaging Approach Using (<i>S</i>)-(−)-[¹⁸F]Fluspidine in Glioblastoma

by Magali Toussaint, Winnie Deuther-Conrad, Mathias Kranz, Steffen Fischer, Friedrich-Alexander Ludwig, Tareq A. Juratli, Marianne Patt, Bernhard Wünsch, Gabriele Schackert, Osama Sabri, Peter Brust
Published 2020-05-01

4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region

by Eva Bollmann, Julian Alexander Schreiber, Nadine Ritter, Stefan Peischard, Huyen Tran Ho, Bernhard Wünsch, Timo Strünker, Sven Meuth, Thomas Budde, Nathalie Strutz-Seebohm, Guiscard Seebohm
Published 2020-04-01

Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R)

by Giacomo Rossino, Marta Rui, Luca Pozzetti, Dirk Schepmann, Bernhard Wünsch, Daniele Zampieri, Giorgia Pellavio, Umberto Laforenza, Silvia Rinaldi, Giorgio Colombo, Laura Morelli, Pasquale Linciano, Daniela Rossi, Simona Collina
Published 2020-10-01

In Vitro Analyses of Novel HCN4 Gene Mutations

by Melina Möller, Nicole Silbernagel, Eva Wrobel, Birgit Stallmayer, Elsie Amedonu, Susanne Rinné, Stefan Peischard, Sven G. Meuth, Bernhard Wünsch, Nathalie Strutz-Seebohm, Niels Decher, Eric Schulze-Bahr, Guiscard Seebohm
Published 2018-09-01

Evaluation of the Enantiomer Specific Biokinetics and Radiation Doses of [18F]Fluspidine—A New Tracer in Clinical Translation for Imaging of σ1 Receptors

by Mathias Kranz, Bernhard Sattler, Nathanael Wüst, Winnie Deuther-Conrad, Marianne Patt, Philipp M. Meyer, Steffen Fischer, Cornelius K. Donat, Bernhard Wünsch, Swen Hesse, Jörg Steinbach, Peter Brust, Osama Sabri
Published 2016-09-01

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm

by Janice K. Jeschke, Cristina Biagioni, Tobias Schierling, Isabel Viola Wagner, Isabel Viola Wagner, Frederik Börgel, Dirk Schepmann, Andreas Schüring, Alexandra E. Kulle, Paul Martin Holterhus, Michael von Wolff, Bernhard Wünsch, Verena Nordhoff, Timo Strünker, Timo Strünker, Christoph Brenker
Published 2021-07-01