AMPK signaling B Raf kinase Note STAT3 protein STAT5 protein STAT5a protein STAT5b protein biological marker cancer growth cancer immunotherapy cancer inhibition cell adhesion cell invasion cell migration cutaneous melanoma cutaneous melanoma cell line extracellular matrix focal adhesion kinase gene activation human hydroxymethylglutaryl coenzyme A reductase kinase immune checkpoint inhibitor immune evasion loss of function mutation metastatic melanoma microsatellite instability nonhuman oncogene N ras pathogenesis phenotype