A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2

by Naila Kuhlmann, Naila Kuhlmann, Austen J. Milnerwood, Austen J. Milnerwood
Published 2020-08-01

Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition

by Chelsie A. Kadgien, Anusha Kamesh, Austen J. Milnerwood
Published 2021-09-01

Chronic and Acute Manipulation of Cortical Glutamate Transmission Induces Structural and Synaptic Changes in Co-cultured Striatal Neurons

by Naila Kuhlmann, Naila Kuhlmann, Miriam Wagner Valladolid, Lucía Quesada-Ramírez, Matthew J. Farrer, Matthew J. Farrer, Austen J. Milnerwood, Austen J. Milnerwood
Published 2021-02-01

P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease

by Jing Fan, Clare M. Gladding, Liang Wang, Lily Y.J. Zhang, Alexandra M. Kaufman, Austen J. Milnerwood, Lynn A. Raymond
Published 2012-03-01

The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation

by Jordan J. Shimell, Bhavin S. Shah, Stuart M. Cain, Samrat Thouta, Naila Kuhlmann, Igor Tatarnikov, D. Blair Jovellar, G. Stefano Brigidi, Jennifer Kass, Austen J. Milnerwood, Terrance P. Snutch, Shernaz X. Bamji
Published 2019-11-01

Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice

by Austen J. Milnerwood, Alexandra M. Kaufman, Marja D. Sepers, Clare M. Gladding, Lily Zhang, Liang Wang, Jing Fan, Ainsley Coquinco, Joy Yi Qiao, Hwan Lee, Yu Tian Wang, Max Cynader, Lynn A. Raymond
Published 2012-10-01

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

by Dayne A Beccano-Kelly, Naila eKuhlmann, Igor eTatarnikov, Mattia eVolta, Lise N Munsie, Patrick eChou, Li-Ping eCao, Heather eHan, Lucia eTapia, Matthew J Farrer, Austen J Milnerwood
Published 2014-09-01

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

by Mattia Volta, Dayne A Beccano-Kelly, Sarah A Paschall, Stefano Cataldi, Sarah E MacIsaac, Naila Kuhlmann, Chelsie A Kadgien, Igor Tatarnikov, Jesse Fox, Jaskaran Khinda, Emma Mitchell, Sabrina Bergeron, Heather Melrose, Matthew J Farrer, Austen J Milnerwood
Published 2017-09-01