From Synaptic Dysfunction to Neuroprotective Strategies in Genetic Parkinson’s Disease: Lessons From LRRK2

by Andrea Mancini, Petra Mazzocchetti, Miriam Sciaccaluga, Alfredo Megaro, Laura Bellingacci, Dayne A. Beccano-Kelly, Massimiliano Di Filippo, Alessandro Tozzi, Paolo Calabresi, Paolo Calabresi
Published 2020-07-01

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

by Dayne A Beccano-Kelly, Naila eKuhlmann, Igor eTatarnikov, Mattia eVolta, Lise N Munsie, Patrick eChou, Li-Ping eCao, Heather eHan, Lucia eTapia, Matthew J Farrer, Austen J Milnerwood
Published 2014-09-01

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

by Mattia Volta, Dayne A Beccano-Kelly, Sarah A Paschall, Stefano Cataldi, Sarah E MacIsaac, Naila Kuhlmann, Chelsie A Kadgien, Igor Tatarnikov, Jesse Fox, Jaskaran Khinda, Emma Mitchell, Sabrina Bergeron, Heather Melrose, Matthew J Farrer, Austen J Milnerwood
Published 2017-09-01