Hepatitis C Virus Evasion Mechanisms from Neutralizing Antibodies

by Arvind H. Patel, Caterina Di Lorenzo, Allan G. N. Angus
Published 2011-11-01

Predicting the Effectiveness of Hepatitis C Virus Neutralizing Antibodies by Bioinformatic Analysis of Conserved Epitope Residues Using Public Sequence Data

by Vanessa M. Cowton, Joshua B. Singer, Robert J. Gifford, Arvind H. Patel
Published 2018-06-01

Design and Synthesis of HCV-E2 Glycoprotein Epitope Mimics in Molecular Construction of Potential Synthetic Vaccines

by Theodorus J. Meuleman, Vanessa M. Cowton, Arvind H. Patel, Rob M. J. Liskamp
Published 2021-02-01

Modeling Human Liver Biology Using Stem Cell-Derived Hepatocytes

by Arvind H. Patel, David C. Hay, Sarah L. Farnworth, Pingnan Sun, Xiaoling Zhou
Published 2013-11-01

Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions.

by Eike Steinmann, Francois Penin, Stephanie Kallis, Arvind H Patel, Ralf Bartenschlager, Thomas Pietschmann
Published 2007-07-01

Dengue Virus Capsid Interacts with DDX3X–A Potential Mechanism for Suppression of Antiviral Functions in Dengue Infection

by Rinki Kumar, Rinki Kumar, Nirpendra Singh, Malik Z. Abdin, Arvind H. Patel, Guruprasad R. Medigeshi
Published 2018-01-01

Expression of DDX3 is directly modulated by hypoxia inducible factor-1 alpha in breast epithelial cells.

by Mahendran Botlagunta, Balaji Krishnamachary, Farhad Vesuna, Paul T Winnard, Guus M Bol, Arvind H Patel, Venu Raman
Published 2011-03-01

Non-random escape pathways from a broadly neutralizing human monoclonal antibody map to a highly conserved region on the hepatitis C virus E2 glycoprotein encompassing amino acids...

by Zhen-yong Keck, Allan G N Angus, Wenyan Wang, Patrick Lau, Yong Wang, Derek Gatherer, Arvind H Patel, Steven K H Foung
Published 2014-08-01

Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer.

by Guus M Bol, Venu Raman, Petra van der Groep, Jeroen F Vermeulen, Arvind H Patel, Elsken van der Wall, Paul J van Diest
Published 2013-01-01

Hepatitis C virus (HCV) infection may elicit neutralizing antibodies targeting epitopes conserved in all viral genotypes.

by Nicasio Mancini, Roberta A Diotti, Mario Perotti, Giuseppe Sautto, Nicola Clementi, Giovanni Nitti, Arvind H Patel, Jonathan K Ball, Massimo Clementi, Roberto Burioni
Published 2009-12-01

Reverse epitope mapping of the E2 glycoprotein in antibody associated hepatitis C virus.

by Amruta S Naik, Ania Owsianka, Brendan A Palmer, Ciaran J O'Halloran, Nicole Walsh, Orla Crosbie, Elizabeth Kenny-Walsh, Arvind H Patel, Liam J Fanning
Published 2017-01-01

Modulating Innate Immunity Improves Hepatitis C Virus Infection and Replication in Stem Cell-Derived Hepatocytes

by Xiaoling Zhou, Pingnan Sun, Baltasar Lucendo-Villarin, Allan G.N. Angus, Dagmara Szkolnicka, Kate Cameron, Sarah L. Farnworth, Arvind H. Patel, David C. Hay
Published 2014-07-01

Protection of hepatocytes from cytotoxic T cell mediated killing by interferon-alpha.

by Christian B Willberg, Scott M Ward, Reginald F Clayton, Nikolai V Naoumov, Christopher McCormick, Sandra Proto, Mark Harris, Arvind H Patel, Paul Klenerman
Published 2007-08-01

Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents.

by Fei Xiao, Isabel Fofana, Laura Heydmann, Heidi Barth, Eric Soulier, François Habersetzer, Michel Doffoël, Jens Bukh, Arvind H Patel, Mirjam B Zeisel, Thomas F Baumert
Published 2014-05-01

Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2

by Ieva Vasiliauskaite, Ania Owsianka, Patrick England, Abdul Ghafoor Khan, Sarah Cole, Dorothea Bankwitz, Steven K. H. Foung, Thomas Pietschmann, Joseph Marcotrigiano, Felix A. Rey, Arvind H. Patel, Thomas Krey, Peter Palese
Published 2017-05-01

Tracking TCRβ sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region

by Mark W Robinson, Mark W Robinson, Joseph eHughes, Gavin S Wilkie, Rachael eSwann, Rachael eSwann, Stephen T Barclay, Peter R Mills, Arvind H Patel, Emma C Thomson, John eMcLauchlan
Published 2016-04-01

Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.

by Zhen-yong Keck, Jinming Xia, Yong Wang, Wenyan Wang, Thomas Krey, Jannick Prentoe, Thomas Carlsen, Angela Ying-Jian Li, Arvind H Patel, Stanley M Lemon, Jens Bukh, Felix A Rey, Steven K H Foung
Published 2012-01-01

Development of a structural epitope mimic: an idiotypic approach to HCV vaccine design

by Vanessa M. Cowton, Ania M. Owsianka, Valeria Fadda, Ana Maria Ortega-Prieto, Sarah J. Cole, Jane A. Potter, Jessica K. Skelton, Nathan Jeffrey, Caterina Di Lorenzo, Marcus Dorner, Garry L. Taylor, Arvind H. Patel
Published 2021-01-01

Immunogenicity and Efficacy of Zika Virus Envelope Domain III in DNA, Protein, and ChAdOx1 Adenoviral-Vectored Vaccines

by César López-Camacho, Giuditta De Lorenzo, Jose Luis Slon-Campos, Stuart Dowall, Peter Abbink, Rafael A. Larocca, Young Chan Kim, Monica Poggianella, Victoria Graham, Stephen Findlay-Wilson, Emma Rayner, Jennifer Carmichael, Wanwisa Dejnirattisai, Michael Boyd, Roger Hewson, Juthathip Mongkolsapaya, Gavin R. Screaton, Dan H. Barouch, Oscar R. Burrone, Arvind H. Patel, Arturo Reyes-Sandoval
Published 2020-06-01

Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

by M Azim Ansari, Elihu Aranday-Cortes, Camilla LC Ip, Ana da Silva Filipe, Siu Hin Lau, Connor Bamford, David Bonsall, Amy Trebes, Paolo Piazza, Vattipally Sreenu, Vanessa M Cowton, STOP-HCV Consortium, Emma Hudson, Rory Bowden, Arvind H Patel, Graham R Foster, William L Irving, Kosh Agarwal, Emma C Thomson, Peter Simmonds, Paul Klenerman, Chris Holmes, Eleanor Barnes, Chris CA Spencer, John McLauchlan, Vincent Pedergnana
Published 2019-09-01