The effects of age and systemic metabolism on anti-tumor T cell responses

by Jefte M Drijvers, Arlene H Sharpe, Marcia C Haigis
Published 2020-11-01

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

by Peter T. Sage, Catherine L. Tan, Gordon J. Freeman, Marcia Haigis, Arlene H. Sharpe
Published 2015-07-01

CD28 costimulation regulates genome-wide effects on alternative splicing.

by Manish J Butte, Sun Jung Lee, Jonathan Jesneck, Mary E Keir, W Nicholas Haining, Arlene H Sharpe
Published 2012-01-01

Helicobacter pylori cag pathogenicity island's role in B7-H1 induction and immune evasion.

by Taslima T Lina, Shatha Alzahrani, Jennifer House, Yoshio Yamaoka, Arlene H Sharpe, Bill A Rampy, Irina V Pinchuk, Victor E Reyes
Published 2015-01-01

CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease.

by Shunsuke Sakai, Keith D Kauffman, Michelle A Sallin, Arlene H Sharpe, Howard A Young, Vitaly V Ganusov, Daniel L Barber
Published 2016-05-01

T Cell Activation Depends on Extracellular Alanine

by Noga Ron-Harel, Jonathan M. Ghergurovich, Giulia Notarangelo, Martin W. LaFleur, Yoshiki Tsubosaka, Arlene H. Sharpe, Joshua D. Rabinowitz, Marcia C. Haigis
Published 2019-09-01

Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection.

by Hadi Maazi, Abinav K Singh, Anneliese O Speak, Vincent Lombardi, Jonathan Lam, Bryant Khoo, Kyung Soo Inn, Arlene H Sharpe, Jae U Jung, Omid Akbari
Published 2013-01-01

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses.

by Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi
Published 2014-01-01

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

by Doumet Georges Helou, Pedram Shafiei-Jahani, Richard Lo, Emily Howard, Benjamin P. Hurrell, Lauriane Galle-Treger, Jacob D. Painter, Gavin Lewis, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Published 2020-08-01

PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma

by Emily Howard, Benjamin P. Hurrell, Doumet Georges Helou, Christine Quach, Jacob D. Painter, Pedram Shafiei-Jahani, Marshall Fung, Parkash S. Gill, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari, Omid Akbari
Published 2021-08-01

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 ann...

by Andrew Zloza, A. Karolina Palucka, Lisa M. Coussens, Philip J. Gotwals, Mark B. Headley, Elizabeth M. Jaffee, Amanda W. Lund, Arlene H. Sharpe, Mario Sznol, Derek A. Wainwright, Kwok-Kin Wong, Marcus W. Bosenberg
Published 2017-09-01

A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system

by Martin W. LaFleur, Thao H. Nguyen, Matthew A. Coxe, Kathleen B. Yates, Justin D. Trombley, Sarah A. Weiss, Flavian D. Brown, Jacob E. Gillis, Daniel J. Coxe, John G. Doench, W. Nicholas Haining, Arlene H. Sharpe
Published 2019-04-01

Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes

by Lauriane Galle-Treger, Ishwarya Sankaranarayanan, Benjamin P. Hurrell, Emily Howard, Richard Lo, Hadi Maazi, Gavin Lewis, Homayon Banie, Alan L. Epstein, Peisheng Hu, Virender K. Rehan, Frank D. Gilliland, Hooman Allayee, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Published 2019-02-01

A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma

by Meghan J. Mooradian, Alexandre Reuben, Peter A. Prieto, Mehlika Hazar-Rethinam, Dennie T. Frederick, Brandon Nadres, Adriano Piris, Vikram Juneja, Zachary A. Cooper, Arlene H. Sharpe, Ryan B. Corcoran, Keith T. Flaherty, Donald P. Lawrence, Jennifer A. Wargo, Ryan J. Sullivan
Published 2018-05-01

PD-1 Dependent Exhaustion of CD8+ T Cells Drives Chronic Malaria

by Joshua M. Horne-Debets, Rebecca Faleiro, Deshapriya S. Karunarathne, Xue Q. Liu, Katie E. Lineburg, Chek Meng Poh, Gijsbert M. Grotenbreg, Geoffrey R. Hill, Kelli P.A. MacDonald, Michael F. Good, Laurent Renia, Rafi Ahmed, Arlene H. Sharpe, Michelle N. Wykes
Published 2013-12-01

Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins

by Sun Hee Yim, Robert A. Everley, Frank A. Schildberg, Sang-Goo Lee, Andrea Orsi, Zachary R. Barbati, Kutay Karatepe, Dmitry E. Fomenko, Petra A. Tsuji, Hongbo R. Luo, Steven P. Gygi, Roberto Sitia, Arlene H. Sharpe, Dolph L. Hatfield, Vadim N. Gladyshev
Published 2018-05-01

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

by Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe
Published 2020-06-01

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.

by Prakash K Gupta, Jernej Godec, David Wolski, Emily Adland, Kathleen Yates, Kristen E Pauken, Cormac Cosgrove, Carola Ledderose, Wolfgang G Junger, Simon C Robson, E John Wherry, Galit Alter, Philip J R Goulder, Paul Klenerman, Arlene H Sharpe, Georg M Lauer, W Nicholas Haining
Published 2015-10-01

Programmed death ligand 2 – A link between inflammation and bone loss in rheumatoid arthritis

by Stinne R. Greisen, Tue W. Kragstrup, Jesper Skovhus Thomsen, Aida Solhøj Hansen, Akilan Krishnamurthy, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Lykke Midtbøll Ørnbjerg, Peter Junker, Arlene H. Sharpe, Gordon J. Freeman, Lakshmanan Annamalai, Malene Hvid, Søren K. Moestrup, Ellen-Margrethe Hauge, Anca Irinel Catrina, Bent Deleuran
Published 2020-01-01

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

by Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier
Published 2015-05-01