Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.

by Saba N Baskoylu, Jill Yersak, Patrick O'Hern, Sarah Grosser, Jonah Simon, Sarah Kim, Kelsey Schuch, Maria Dimitriadi, Katherine S Yanagi, Jeremy Lins, Anne C Hart
Published 2018-10-01

Decreased microRNA levels lead to deleterious increases in neuronal M2 muscarinic receptors in Spinal Muscular Atrophy models

by Patrick J O'Hern, Inês do Carmo G. Gonçalves, Johanna Brecht, Eduardo Javier López Soto, Jonah Simon, Natalie Chapkis, Diane Lipscombe, Min Jeong Kye, Anne C Hart
Published 2017-05-01