Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16

by George Khelashvili, Maria E. Falzone, Xiaolu Cheng, Byoung-Cheol Lee, Alessio Accardi, Harel Weinstein
Published 2019-10-01

Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

by Byoung-Cheol Lee, George Khelashvili, Maria Falzone, Anant K. Menon, Harel Weinstein, Alessio Accardi
Published 2018-08-01

Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels

by Lilia Leisle, Yanyan Xu, Eva Fortea, Sangyun Lee, Jason D Galpin, Malvin Vien, Christopher A Ahern, Alessio Accardi, Simon Bernèche
Published 2020-04-01

Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase

by Maria E Falzone, Jan Rheinberger, Byoung-Cheol Lee, Thasin Peyear, Linda Sasset, Ashleigh M Raczkowski, Edward T Eng, Annarita Di Lorenzo, Olaf S Andersen, Crina M Nimigean, Alessio Accardi
Published 2019-01-01

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

by Simon R. Bushell, Ashley C. W. Pike, Maria E. Falzone, Nils J. G. Rorsman, Chau M. Ta, Robin A. Corey, Thomas D. Newport, John C. Christianson, Lara F. Scofano, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, James D. Love, Nicola A. Burgess-Brown, Rebecca Sitsapesan, Phillip J. Stansfeld, Juha T. Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P. Carpenter
Published 2019-09-01