Look and Outlook on Enzyme-Mediated Macrolide Resistance

by Tolou Golkar, Michał Zieliński, Albert M. Berghuis, Albert M. Berghuis
Published 2018-08-01

Prospects for circumventing aminoglycoside kinase mediated antibiotic resistance

by Kun eShi, Shane J. Caldwell, Desiree H. Fong, Albert M. Berghuis, Albert M. Berghuis
Published 2013-06-01

Structural and functional insights into esterase-mediated macrolide resistance

by Michał Zieliński, Jaeok Park, Barry Sleno, Albert M. Berghuis
Published 2021-03-01

Crystal structures of two aminoglycoside kinases bound with a eukaryotic protein kinase inhibitor.

by Desiree H Fong, Bing Xiong, Jiyoung Hwang, Albert M Berghuis
Published 2011-05-01

Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product

by Jaeok Park, Michal Zielinski, Alexandr Magder, Youla S. Tsantrizos, Albert M. Berghuis
Published 2017-01-01

Phosphonate and Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthases: A Structure-Guided Perspective

by Jaeok Park, Vishal R. Pandya, Sean J. Ezekiel, Albert M. Berghuis
Published 2021-01-01

Human Isoprenoid Synthase Enzymes as Therapeutic Targets

by Jaeok ePark, Alexios eMatralis, Albert M. Berghuis, Youla S Tsantrizos
Published 2014-07-01

Structural basis for plazomicin antibiotic action and resistance

by Tolou Golkar, Angelia V. Bassenden, Krishnagopal Maiti, Dev P. Arya, T. Martin Schmeing, Albert M. Berghuis
Published 2021-06-01

Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase.

by Jaeok Park, Dmitry Rodionov, Joris W De Schutter, Yih-Shyan Lin, Youla S Tsantrizos, Albert M Berghuis
Published 2017-01-01

Structural and phylogenetic analyses of resistance to next-generation aminoglycosides conferred by AAC(2′) enzymes

by Angelia V. Bassenden, Linda Dumalo, Jaeok Park, Jonathan Blanchet, Krishnagopal Maiti, Dev P. Arya, Albert M. Berghuis
Published 2021-06-01

Identification of the adenovirus E4orf4 protein binding site on the B55α and Cdc55 regulatory subunits of PP2A: Implications for PP2A function, tumor cell killing and viral replica...

by Melissa Z Mui, Michael Kucharski, Marie-Joëlle Miron, Woosuk Steve Hur, Albert M Berghuis, Paola Blanchette, Philip E Branton
Published 2013-01-01

Structural analysis of a novel cyclohexylamine oxidase from Brevibacterium oxydans IH-35A.

by I Ahmad Mirza, David L Burk, Bing Xiong, Hiroaki Iwaki, Yoshie Hasegawa, Stephan Grosse, Peter C K Lau, Albert M Berghuis
Published 2013-01-01

A potential gain-of-function variant of SLC9A6 leads to endosomal alkalinization and neuronal atrophy associated with Christianson Syndrome

by Alina Ilie, Andy Y.L. Gao, Annie Boucher, Jaeok Park, Albert M. Berghuis, Mariëtte J.V. Hoffer, Yvonne Hilhorst-Hofstee, R. Anne McKinney, John Orlowski
Published 2019-01-01

Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues

by Jacynthe L. Toulouse, Brahm J. Yachnin, Edward H. Ruediger, Daniel Deon, Marc Gagnon, Kévin Saint-Jacques, Maximilian C. C. J. C. Ebert, Delphine Forge, Dominic Bastien, Damien Y. Colin, Jean Jacques Vanden Eynde, Anne Marinier, Albert M. Berghuis, Joelle N. Pelletier
Published 2019-06-01

TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw

by Carolina Cavalieri Gomes, Tenzin Gayden, Andrea Bajic, Osama F. Harraz, Jonathan Pratt, Hamid Nikbakht, Eric Bareke, Marina Gonçalves Diniz, Wagner Henriques Castro, Pascal St-Onge, Daniel Sinnett, HyeRim Han, Barbara Rivera, Leonie G. Mikael, Nicolas De Jay, Claudia L. Kleinman, Elvis Terci Valera, Angelia V. Bassenden, Albert M. Berghuis, Jacek Majewski, Mark T. Nelson, Ricardo Santiago Gomez, Nada Jabado
Published 2018-11-01