Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity.

by Kwadwo A Kusi, Bart W Faber, Alan W Thomas, Edmond J Remarque
Published 2009-12-01

Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response.

by Kwadwo A Kusi, Bart W Faber, Vanessa Riasat, Alan W Thomas, Clemens H M Kocken, Edmond J Remarque
Published 2010-11-01

A malaria vaccine based on the polymorphic block 2 region of MSP-1 that elicits a broad serotype-spanning immune response.

by Graeme J M Cowan, Alison M Creasey, Kelwalin Dhanasarnsombut, Alan W Thomas, Edmond J Remarque, David R Cavanagh
Published 2011-01-01

Prospective identification of malaria parasite genes under balancing selection.

by Kevin K A Tetteh, Lindsay B Stewart, Lynette Isabella Ochola, Alfred Amambua-Ngwa, Alan W Thomas, Kevin Marsh, Gareth D Weedall, David J Conway
Published 2009-01-01

Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody.

by Brigitte Vulliez-Le Normand, Bart W Faber, Frederick A Saul, Marjolein van der Eijk, Alan W Thomas, Balbir Singh, Clemens H M Kocken, Graham A Bentley
Published 2015-01-01

Vaccination with Plasmodium knowlesi AMA1 formulated in the novel adjuvant co-vaccine HT™ protects against blood-stage challenge in rhesus macaques.

by Muzamil Mahdi Abdel Hamid, Edmond J Remarque, Leonie M van Duivenvoorde, Nicole van der Werff, Vanessa Walraven, Bart W Faber, Clemens H M Kocken, Alan W Thomas
Published 2011-01-01

Humoral immune responses to a single allele PfAMA1 vaccine in healthy malaria-naïve adults.

by Edmond J Remarque, Meta Roestenberg, Sumera Younis, Vanessa Walraven, Nicole van der Werff, Bart W Faber, Odile Leroy, Robert Sauerwein, Clemens H M Kocken, Alan W Thomas
Published 2012-01-01

Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?

by R Alan Wilson, Jan A M Langermans, Govert J van Dam, Richard A Vervenne, Stephanie L Hall, William C Borges, Gary P Dillon, Alan W Thomas, Patricia S Coulson
Published 2008-09-01

Antibody responses to a novel Plasmodium falciparum merozoite surface protein vaccine correlate with protection against experimental malaria infection in Aotus monkeys.

by David R Cavanagh, Clemens H M Kocken, John H White, Graeme J M Cowan, Kay Samuel, Martin A Dubbeld, Annemarie Voorberg-van der Wel, Alan W Thomas, Jana S McBride, David E Arnot
Published 2014-01-01

Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation.

by Bart W Faber, Stephan Hellwig, Sophie Houard, Nicolas Havelange, Jürgen Drossard, Hubert Mertens, Alexander Croon, Robin Kastilan, Richard Byrne, Nicole van der Werff, Marjolein van der Eijk, Alan W Thomas, Clemens H M Kocken, Edmond J Remarque
Published 2016-01-01

The RON2-AMA1 interaction is a critical step in moving junction-dependent invasion by apicomplexan parasites.

by Mauld Lamarque, Sébastien Besteiro, Julien Papoin, Magali Roques, Brigitte Vulliez-Le Normand, Juliette Morlon-Guyot, Jean-François Dubremetz, Sylvain Fauquenoy, Stanislas Tomavo, Bart W Faber, Clemens H Kocken, Alan W Thomas, Martin J Boulanger, Graham A Bentley, Maryse Lebrun
Published 2011-01-01

Transgenic fluorescent Plasmodium cynomolgi liver stages enable live imaging and purification of Malaria hypnozoite-forms.

by Annemarie Voorberg-van der Wel, Anne-Marie Zeeman, Sandra M van Amsterdam, Alexander van den Berg, Els J Klooster, Shiroh Iwanaga, Chris J Janse, Geert-Jan van Gemert, Robert Sauerwein, Niels Beenhakker, Gerrit Koopman, Alan W Thomas, Clemens H M Kocken
Published 2013-01-01

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery.

by Laurent Dembele, Audrey Gego, Anne-Marie Zeeman, Jean-François Franetich, Olivier Silvie, Armelle Rametti, Roger Le Grand, Nathalie Dereuddre-Bosquet, Robert Sauerwein, Geert-Jan van Gemert, Jean-Christophe Vaillant, Alan W Thomas, Georges Snounou, Clemens H M Kocken, Dominique Mazier
Published 2011-03-01

Correction: MVA.85A Boosting of BCG and an Attenuated, phoP Deficient M. tuberculosis Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques

by Frank A. W. Verreck, Richard A. W. Vervenne, Ivanela Kondova, Klaas W. van Kralingen, Edmond J. Remarque, Gerco Braskamp, Nicole M. van der Werff, Ariena Kersbergen, Tom H. M. Ottenhoff, Peter J. Heidt, Sarah C. Gilbert, Brigitte Gicquel, Adrian V. S. Hill, Carlos Martin, Helen McShane, Alan W. Thomas
Published 2011-01-01

MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques.

by Frank A W Verreck, Richard A W Vervenne, Ivanela Kondova, Klaas W van Kralingen, Edmond J Remarque, Gerco Braskamp, Nicole M van der Werff, Ariena Kersbergen, Tom H M Ottenhoff, Peter J Heidt, Sarah C Gilbert, Brigitte Gicquel, Adrian V S Hill, Carlos Martin, Helen McShane, Alan W Thomas
Published 2009-01-01

Correction: MVA.85A Boosting of BCG and an Attenuated, Deficient Vaccine Both Show Protective Efficacy Against Tuberculosis in Rhesus Macaques.

by Frank A. W. Verreck, Richard A. W. Vervenne, Ivanela Kondova, Klaas W. van Kralingen, Edmond J. Remarque, Gerco Braskamp, Nicole M. van der Werff, Ariena Kersbergen, Tom H. M. Ottenhoff, Peter J. Heidt, Sarah C. Gilbert, Brigitte Gicquel, Adrian V. S. Hill, Carlos Martin, Helen McShane, Alan W. Thomas
Published 2011-01-01