Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates

by Adriana Savastano, Alain Ibáñez de Opakua, Marija Rankovic, Markus Zweckstetter
Published 2020-11-01

Proline/arginine dipeptide repeat polymers derail protein folding in amyotrophic lateral sclerosis

by Maria Babu, Filippo Favretto, Alain Ibáñez de Opakua, Marija Rankovic, Stefan Becker, Markus Zweckstetter
Published 2021-06-01

Co-factor-free aggregation of tau into seeding-competent RNA-sequestering amyloid fibrils

by Pijush Chakraborty, Gwladys Rivière, Shu Liu, Alain Ibáñez de Opakua, Rıza Dervişoğlu, Alina Hebestreit, Loren B. Andreas, Ina M. Vorberg, Markus Zweckstetter
Published 2021-07-01

The metastasis suppressor KISS1 is an intrinsically disordered protein slightly more extended than a random coil.

by Alain Ibáñez de Opakua, Nekane Merino, Maider Villate, Tiago N Cordeiro, Georgina Ormaza, Marta Sánchez-Carbayo, Tammo Diercks, Pau Bernadó, Francisco J Blanco
Published 2017-01-01

The Gαi-GIV binding interface is a druggable protein-protein interaction

by Vincent DiGiacomo, Alain Ibáñez de Opakua, Maria P. Papakonstantinou, Lien T. Nguyen, Nekane Merino, Juan B. Blanco-Canosa, Francisco J. Blanco, Mikel Garcia-Marcos
Published 2017-08-01

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif

by Alain Ibáñez de Opakua, Kshitij Parag-Sharma, Vincent DiGiacomo, Nekane Merino, Anthony Leyme, Arthur Marivin, Maider Villate, Lien T. Nguyen, Miguel Angel de la Cruz-Morcillo, Juan B. Blanco-Canosa, Sekar Ramachandran, George S. Baillie, Richard A. Cerione, Francisco J. Blanco, Mikel Garcia-Marcos
Published 2017-05-01