Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis

by Ssu-Hsueh Tseng, Sung-Taek Park, Brandon Lam, Ya-Chea Tsai, Max A Cheng, Emily Farmer, Deyin Xing
Published 2020-06-01

Xenogeneic human p53 DNA vaccination by electroporation breaks immune tolerance to control murine tumors expressing mouse p53.

by Ruey-Shyang Soong, Janson Trieu, Sung Yong Lee, Liangmei He, Ya-Chea Tsai, T-C Wu, Chien-Fu Hung
Published 2013-01-01

Direct T cell activation via CD40 ligand generates high avidity CD8+ T cells capable of breaking immunological tolerance for the control of tumors.

by Ruey-Shyang Soong, Liwen Song, Janson Trieu, Sung Yong Lee, Liangmei He, Ya-Chea Tsai, T-C Wu, Chien-Fu Hung
Published 2014-01-01

Tumor-targeted delivery of IL-2 by NKG2D leads to accumulation of antigen-specific CD8+ T cells in the tumor loci and enhanced anti-tumor effects.

by Tae Heung Kang, Chih-Ping Mao, Liangmei He, Ya-Chea Tsai, Katherine Liu, Victor La, T-C Wu, Chien-Fu Hung
Published 2012-01-01

A novel pseudovirus‐based mouse model of SARS-CoV-2 infection to test COVID-19 interventions

by Ssu-Hsueh Tseng, Brandon Lam, Yu Jui Kung, John Lin, Li Liu, Ya Chea Tsai, Louise Ferrall, Richard B. S. Roden, T. C. Wu, Chien-Fu Hung
Published 2021-04-01