Xenogeneic human p53 DNA vaccination by electroporation breaks immune tolerance to control murine tumors expressing mouse p53.

by Ruey-Shyang Soong, Janson Trieu, Sung Yong Lee, Liangmei He, Ya-Chea Tsai, T-C Wu, Chien-Fu Hung
Published 2013-01-01

Direct T cell activation via CD40 ligand generates high avidity CD8+ T cells capable of breaking immunological tolerance for the control of tumors.

by Ruey-Shyang Soong, Liwen Song, Janson Trieu, Sung Yong Lee, Liangmei He, Ya-Chea Tsai, T-C Wu, Chien-Fu Hung
Published 2014-01-01

Tumor-targeted delivery of IL-2 by NKG2D leads to accumulation of antigen-specific CD8+ T cells in the tumor loci and enhanced anti-tumor effects.

by Tae Heung Kang, Chih-Ping Mao, Liangmei He, Ya-Chea Tsai, Katherine Liu, Victor La, T-C Wu, Chien-Fu Hung
Published 2012-01-01