Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model

by Ling Wu, Joanna Brzostek, Shvetha Sankaran, Qianru Wei, Jiawei Yap, Triscilla Y.Y. Tan, Junyun Lai, Paul A. MacAry, Nicholas R. J. Gascoigne
Published 2021-02-01

Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice

by Mukul Prasad, Mukul Prasad, Mukul Prasad, Lukasz Wojciech, Lukasz Wojciech, Joanna Brzostek, Joanna Brzostek, Joanna Brzostek, Jianfang Hu, Yen Leong Chua, Yen Leong Chua, Yen Leong Chua, Desmond Wai Hon Tung, Desmond Wai Hon Tung, Jiawei Yap, Jiawei Yap, Vasily Rybakin, Vasily Rybakin, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne
Published 2021-04-01

Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling

by Xiang Zhao, Shvetha Sankaran, Jiawei Yap, Chien Tei Too, Zi Zong Ho, Garry Dolton, Mateusz Legut, Ee Chee Ren, Andrew K. Sewell, Antonio Bertoletti, Paul A. MacAry, Joanna Brzostek, Nicholas R. J. Gascoigne
Published 2018-07-01

Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01

by Yue Gu, Yee Hwa Wong, Chong Wai Liew, Conrad E. Z. Chan, Tanusya M. Murali, Jiawei Yap, Chien Tei Too, Kiren Purushotorman, Maryam Hamidinia, Abbas El Sahili, Angeline T. H. Goh, Rachel Z. C. Teo, Kathryn J. Wood, Brendon J. Hanson, Nicholas R. J. Gascoigne, Julien Lescar, Anantharaman Vathsala, Paul A. MacAry
Published 2019-02-01