R and nlmixr as a gateway between statistics and pharmacometrics

by Matthew Fidler, Richard Hooijmaijers, Rik Schoemaker, Justin J. Wilkins, Yuan Xiong, Wenping Wang
Published 2021-04-01

Deep Analysis of the Peripheral Immune System in IBD Reveals New Insight in Disease Subtyping and Response to Monotherapy or Combination TherapySummary

by Roman Kosoy, Seunghee Kim-Schulze, Adeeb Rahman, Joshua R. Friedman, Ruiqi Huang, Lauren A. Peters, El-ad Amir, Jacqueline Perrigoue, Aleksandar Stojmirovic, Won-min Song, Hao Ke, Ryan Ungaro, Saurabh Mehandru, Judy Cho, Marla Dubinsky, Mark Curran, Carrie Brodmerkel, Eric E. Schadt, Bruce E. Sands, Jean-Frederic Colombel, Andrew Kasarskis, Carmen A. Argmann, Mayte Suárez-Fariñas
Published 2021-01-01

PromarkerD Predicts Renal Function Decline in Type 2 Diabetes in the Canagliflozin Cardiovascular Assessment Study (CANVAS)

by Kirsten E. Peters, Jialin Xu, Scott D. Bringans, Wendy A. Davis, Timothy M.E. Davis, Michael K. Hansen, Richard J. Lipscombe
Published 2020-10-01

TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β

by Ricardo da Silva Antunes, Amit K. Mehta, Lisa Madge, Joel Tocker, Michael Croft, Michael Croft
Published 2018-03-01

A Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line

by Huiyi Cao, Srinivas Mushnoori, Barry Higgins, Chandrasekhar Kollipara, Adam Fermier, Douglas Hausner, Shantenu Jha, Ravendra Singh, Marianthi Ierapetritou, Rohit Ramachandran
Published 2018-05-01

CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision

by Karen Rowland Yeo, Stefanie Hennig, Sriram Krishnaswami, Natasha Strydom, Vivaswath S. Ayyar, Jonathan French, Vikram Sinha, Eric Sobie, Ping Zhao, Lena E. Friberg, France Mentré
Published 2021-07-01

Cross‐company collaboration to leverage analytics for clinical quality and accelerate drug development: The IMPALA industry group

by Timothé Ménard, Kyle Young, Laura Siegel, Jennifer Emerson, Robert Studt, Leslie Sidor, The IMPALA Industry Group
Published 2021-08-01

Estimating the Proportion of True Null Hypotheses in Multiple Testing Problems

by Oluyemi Oyeniran, Hanfeng Chen
Published 2016-01-01

Mean seeds, migrating plant awns embedded in a miniature poodle’s bladder wall

by Kathleen Graham Lomax
Published 2021-08-01

Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations?

by Vasanthanathan Poongavanam, Emma Danelius, Stefan Peintner, Lilian Alcaraz, Giulia Caron, Maxwell D. Cummings, Stanislaw Wlodek, Mate Erdelyi, Paul C. D. Hawkins, Giuseppe Ermondi, Jan Kihlberg
Published 2018-09-01

PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer

by Edith M Janssen, Hannah S Newton, Vaibhavkumar S Gawali, Ameet A Chimote, Maria A Lehn, Sarah M Palackdharry, Benjamin H Hinrichs, Roman Jandarov, David Hildeman, Trisha M Wise-Draper
Published 2020-07-01

Relationship Between Sleep and Behavior in Autism Spectrum Disorder: Exploring the Impact of Sleep Variability

by Abigail Bangerter, Meenakshi Chatterjee, Nikolay V. Manyakov, Seth Ness, David Lewin, Andrew Skalkin, Matthew Boice, Matthew S. Goodwin, Geraldine Dawson, Robert Hendren, Bennett Leventhal, Frederick Shic, Frederick Shic, Anna Esbensen, Anna Esbensen, Gahan Pandina
Published 2020-03-01

Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach

by Karima Habbout, Junichi Omura, Charifa Awada, Alice Bourgeois, Yann Grobs, Vinod Krishna, Sandra Breuils-Bonnet, Eve Tremblay, Ghada Mkannez, Sandra Martineau, Valérie Nadeau, Florence Roux-Dalvai, Mark Orcholski, Jey Jeyaseelan, David Gutstein, François Potus, Steeve Provencher, Sébastien Bonnet, Roxane Paulin, Olivier Boucherat
Published 2021-03-01

Cardiac Safety Assessment of Lazertinib: Findings From Patients With EGFR Mutation-Positive Advanced NSCLC and Preclinical Studies

by Seong Bok Jang, PhD, Kyeong Bae Kim, PhD, Sujin Sim, MS, Byoung Chul Cho, MD, PhD, Myung-Ju Ahn, MD, PhD, Ji-Youn Han, MD, PhD, Sang-We Kim, MD, PhD, Ki Hyeong Lee, MD, PhD, Eun Kyung Cho, MD, PhD, Nahor Haddish-Berhane, PhD, Jaydeep Mehta, PharmD, PhD, Se-Woong Oh, PhD
Published 2021-10-01

Functionally Mature CD1c+ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium

by Mary Canavan, Mary Canavan, Viviana Marzaioli, Viviana Marzaioli, Vipul Bhargava, Sunil Nagpal, Phil Gallagher, Conor Hurson, Ronan Mullan, Douglas J. Veale, Ursula Fearon, Ursula Fearon
Published 2021-10-01

Fragment Binding to β‑Secretase 1 without Catalytic Aspartate Interactions Identified via Orthogonal Screening Approaches

by Frederik J. R. Rombouts, Richard Alexander, Erna Cleiren, Alex De Groot, Michel Carpentier, Joyce Dijkmans, Katleen Fierens, Stefan Masure, Diederik Moechars, Martina Palomino-Schätzlein, Antonio Pineda-Lucena, Andrés A. Trabanco, Daan Van Glabbeek, Ann Vos, Gary Tresadern
Published 2017-02-01

EFFICACY AND SAFETY OF CARFILZOMIB, DEXAMETHASONE, DARATUMUMAB TWICE-WEEKLY AT 56 MG/M2 AND ONCE-WEEKLY AT 70 MG/M2 IN RELAPSED OR REFRACTORY MULTIPLE MYELOMA: CROSS-STUDY COMPARIS...

by X. Leleu, M. Beksac, T. Chou, M.A. Dimopoulos, S. Yoon, H.M. Prince, A. Chari, A. Oriol, D.S.D. Siegel, M. Khurana, M. Qi, M. Obreja, L. Pour, T. Shelekhova
Published 2020-11-01

Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor

by Yu Cai, Jun Yu, Ping Ren, Jianlin He, Zhipeng Wu, Kun Xiao, Hong Jia, Jian Wang, Yang Sai, Guangxiu Dai, Xiong Li, Weiguo Su, Karen Ngo, Glenda Castro, Paul D. Acton, Wai‐Ping Fung‐Leung, James P. Edwards, Jennifer Venable, Tadimeti S. Rao
Published 2020-02-01

A Dynamic Quantitative Systems Pharmacology Model of Inflammatory Bowel Disease: Part 2 – Application to Current Therapies in Crohn’s Disease

by Katharine V. Rogers, Steven W. Martin, Indranil Bhattacharya, Ravi Shankar Prasad Singh, Satyaprakash Nayak
Published 2021-01-01

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor

by Chan Gao, Michael Quigley, Dandan Zhao, Jennifer Koenitzer, Dan You, Stephen Hillerman, Gregory Locke, Charu Chaudhry, Caitlyn Stromko, Anwar Murtaza, Yi Fan, Yali Chen, Stephanie Briceno, Elizabeth Duperret, Johnni Gullo-Brown, John Feder, Joshua Curtin, Andrew P Degnan, Godwin Kumi, Mark Wittman, Benjamin M Johnson, Karen E Parrish, Giridharan Gokulrangan, John T Hunt, Luisa Salter-Cid, Emma Lees, Jinqi Liu
Published 2021-01-01