Complete representation of a tapeworm genome reveals chromosomes capped by centromeres, necessitating a dual role in segregation and protection

by Peter D. Olson, Alan Tracey, Andrew Baillie, Katherine James, Stephen R. Doyle, Sarah K. Buddenborg, Faye H. Rodgers, Nancy Holroyd, Matt Berriman
Published 2020-11-01

Author Correction: A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

by Guste Urbonaite, Jimmy Tsz Hang Lee, Ping Liu, Guillermo E. Parada, Martin Hemberg, Murat Acar
Published 2021-07-01

Building bridges between cellular and molecular structural biology

by Ardan Patwardhan, Robert Brandt, Sarah J Butcher, Lucy Collinson, David Gault, Kay Grünewald, Corey Hecksel, Juha T Huiskonen, Andrii Iudin, Martin L Jones, Paul K Korir, Abraham J Koster, Ingvar Lagerstedt, Catherine L Lawson, David Mastronarde, Matthew McCormick, Helen Parkinson, Peter B Rosenthal, Stephan Saalfeld, Helen R Saibil, Sirarat Sarntivijai, Irene Solanes Valero, Sriram Subramaniam, Jason R Swedlow, Ilinca Tudose, Martyn Winn, Gerard J Kleywegt
Published 2017-07-01

Genetic effects on promoter usage are highly context-specific and contribute to complex traits

by Kaur Alasoo, Julia Rodrigues, John Danesh, Daniel F Freitag, Dirk S Paul, Daniel J Gaffney
Published 2019-01-01

Lyplal1 is dispensable for normal fat deposition in mice

by Rachel A. Watson, Amy S. Gates, Elizabeth H. Wynn, Fiona E. Calvert, Amandine Girousse, Christopher J. Lelliott, Inês Barroso
Published 2017-12-01

The Col4a2em1(IMPC)Wtsi mouse line: lessons from the Deciphering the Mechanisms of Developmental Disorders program

by Lukas F. Reissig, Anna Nele Herdina, Julia Rose, Barbara Maurer-Gesek, Jenna L. Lane, Fabrice Prin, Robert Wilson, Emily Hardman, Antonella Galli, Catherine Tudor, Elizabeth Tuck, Cecilia Icoresi-Mazzeo, Jacqueline K. White, Ed Ryder, Diane Gleeson, David J. Adams, Stefan H. Geyer, Timothy J. Mohun, Wolfgang J. Weninger
Published 2019-08-01

Flexible and scalable diagnostic filtering of genomic variants using G2P with Ensembl VEP

by Anja Thormann, Mihail Halachev, William McLaren, David J. Moore, Victoria Svinti, Archie Campbell, Shona M. Kerr, Marc Tischkowitz, Sarah E. Hunt, Malcolm G. Dunlop, Matthew E. Hurles, Caroline F. Wright, Helen V. Firth, Fiona Cunningham, David R. FitzPatrick
Published 2019-05-01

Transcriptional activity and strain-specific history of mouse pseudogenes

by Cristina Sisu, Paul Muir, Adam Frankish, Ian Fiddes, Mark Diekhans, David Thybert, Duncan T. Odom, Paul Flicek, Thomas M. Keane, Tim Hubbard, Jennifer Harrow, Mark Gerstein
Published 2020-07-01

Population-scale proteome variation in human induced pluripotent stem cells

by Bogdan Andrei Mirauta, Daniel D Seaton, Dalila Bensaddek, Alejandro Brenes, Marc Jan Bonder, Helena Kilpinen, HipSci Consortium, Oliver Stegle, Angus I Lamond
Published 2020-08-01

Somatic mosaicism and common genetic variation contribute to the risk of very-early-onset inflammatory bowel disease

by Eva Gonçalves Serra, Tobias Schwerd, Loukas Moutsianas, Athena Cavounidis, Laura Fachal, Sumeet Pandey, Jochen Kammermeier, Nicholas M. Croft, Carsten Posovszky, Astor Rodrigues, Richard K. Russell, Farah Barakat, Marcus K. H. Auth, Robert Heuschkel, Matthias Zilbauer, Krzysztof Fyderek, Christian Braegger, Simon P. Travis, Jack Satsangi, Miles Parkes, Nikhil Thapar, Helen Ferry, Julie C. Matte, Kimberly C. Gilmour, Andrzej Wedrychowicz, Peter Sullivan, Carmel Moore, Jennifer Sambrook, Willem Ouwehand, David Roberts, John Danesh, Toni A. Baeumler, Tudor A. Fulga, Mohammad Karaminejadranjbar, Ahmed Ahmed, Rachel Wilson, Jeffrey C. Barrett, Abdul Elkadri, Anne M. Griffiths, COLORS in IBD group investigators, Oxford IBD cohort study investigators, INTERVAL Study, Swiss IBD cohort investigators, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Scott B. Snapper, Neil Shah, Aleixo M. Muise, David C. Wilson, Holm H. Uhlig, Carl A. Anderson
Published 2020-02-01

Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth

by Sarah Davidson, Mirjana Efremova, Angela Riedel, Bidesh Mahata, Jhuma Pramanik, Jani Huuhtanen, Gozde Kar, Roser Vento-Tormo, Tzachi Hagai, Xi Chen, Muzlifah A. Haniffa, Jacqueline D. Shields, Sarah A. Teichmann
Published 2020-05-01

CLIMB-COVID: continuous integration supporting decentralised sequencing for SARS-CoV-2 genomic surveillance

by Samuel M. Nicholls, Radoslaw Poplawski, Matthew J. Bull, Anthony Underwood, Michael Chapman, Khalil Abu-Dahab, Ben Taylor, Rachel M. Colquhoun, Will P. M. Rowe, Ben Jackson, Verity Hill, Áine O’Toole, Sara Rey, Joel Southgate, Roberto Amato, Rich Livett, Sónia Gonçalves, Ewan M. Harrison, Sharon J. Peacock, David M. Aanensen, Andrew Rambaut, Thomas R. Connor, Nicholas J. Loman, The COVID-19 Genomics UK (COG-UK) Consortium
Published 2021-07-01

Haplosaurus computes protein haplotypes for use in precision drug design

by William Spooner, William McLaren, Timothy Slidel, Donna K. Finch, Robin Butler, Jamie Campbell, Laura Eghobamien, David Rider, Christine Mione Kiefer, Matthew J. Robinson, Colin Hardman, Fiona Cunningham, Tristan Vaughan, Paul Flicek, Catherine Chaillan Huntington
Published 2018-10-01

A yeast-optimized single-cell transcriptomics platform elucidates how mycophenolic acid and guanine alter global mRNA levels

by Guste Urbonaite, Jimmy Tsz Hang Lee, Ping Liu, Guillermo E. Parada, Martin Hemberg, Murat Acar
Published 2021-06-01

Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts

by Ilias Georgakopoulos-Soares, Gene Koh, Sophie E. Momen, Josef Jiricny, Martin Hemberg, Serena Nik-Zainal
Published 2020-04-01

Validating the concept of mutational signatures with isogenic cell models

by Xueqing Zou, Michel Owusu, Rebecca Harris, Stephen P. Jackson, Joanna I. Loizou, Serena Nik-Zainal
Published 2018-05-01

JAMI: a Java library for molecular interactions and data interoperability

by M. Sivade (Dumousseau), M. Koch, A. Shrivastava, D. Alonso-López, J. De Las Rivas, N. del-Toro, C. W. Combe, B. H. M. Meldal, J. Heimbach, J. Rappsilber, J. Sullivan, Y. Yehudi, S. Orchard
Published 2018-04-01

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

by Sougata Roy, James Sipthorp, Bidesh Mahata, Jhuma Pramanik, Marco L. Hennrich, Anne-Claude Gavin, Steven V. Ley, Sarah A. Teichmann
Published 2021-05-01

Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

by Emily S. Wong, Bianca M. Schmitt, Anastasiya Kazachenka, David Thybert, Aisling Redmond, Frances Connor, Tim F. Rayner, Christine Feig, Anne C. Ferguson-Smith, John C. Marioni, Duncan T. Odom, Paul Flicek
Published 2017-10-01

Staged developmental mapping and X chromosome transcriptional dynamics during mouse spermatogenesis

by Christina Ernst, Nils Eling, Celia P. Martinez-Jimenez, John C. Marioni, Duncan T. Odom
Published 2019-03-01