Chylomicronemia from GPIHBP1 autoantibodies

by Kazuya Miyashita, Jens Lutz, Lisa C. Hudgins, Dana Toib, Ambika P. Ashraf, Wenxin Song, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Published 2020-11-01

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia

by Xuchen Hu, Thomas A Weston, Cuiwen He, Rachel S Jung, Patrick J Heizer, Brian D Young, Yiping Tu, Peter Tontonoz, James A Wohlschlegel, Haibo Jiang, Stephen G Young, Loren G Fong
Published 2019-09-01

Deletion of the basement membrane heparan sulfate proteoglycan type XVIII collagen causes hypertriglyceridemia in mice and humans.

by Joseph R Bishop, Maria Rita Passos-Bueno, Loren Fong, Kristin I Stanford, Jon C Gonzales, Erika Yeh, Stephen G Young, Andre Bensadoun, Joseph L Witztum, Jeffrey D Esko, Karen S Moulton
Published 2010-11-01

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

by Brandon S.J. Davies, Shao H. Yang, Emily Farber, Roger Lee, Suzanne B. Buck, Douglas A. Andres, H. Peter Spielmann, Brian J. Agnew, Fuyuhiko Tamanoi, Loren G. Fong, Stephen G. Young
Published 2009-01-01

Sphingosine-1-phosphate lyase expression in embryonic and adult murine tissues

by Alexander D. Borowsky, Padmavathi Bandhuvula, Ashok Kumar, Yuko Yoshinaga, Mikhail Nefedov, Loren G. Fong, Meng Zhang, Brian Baridon, Lisa Dillard, Pieter de Jong, Stephen G. Young, David B. West, Julie D. Saba
Published 2012-09-01

Assessing mechanisms of GPIHBP1 and lipoprotein lipase movement across endothelial cells[S]

by Brandon S.J. Davies, Chris N. Goulbourne, Richard H. Barnes, II, Kirsten A. Turlo, Peter Gin, Sue Vaughan, David J. Vaux, André Bensadoun, Anne P. Beigneux, Loren G. Fong, Stephen G. Young
Published 2012-12-01

High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins

by Matthias Schneider, Joseph L. Witztum, Stephen G. Young, Erwin H. Ludwig, Elizabeth R. Miller, Sotirios Tsimikas, Linda K. Curtiss, Santica M. Marcovina, John M. Taylor, Richard M. Lawn, Thomas L. Innerarity, Robert E. Pitas
Published 2005-04-01

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia

by Gunilla Olivecrona, Ewa Ehrenborg, Henrik Semb, Elena Makoveichuk, Anna Lindberg, Michael R. Hayden, Peter Gin, Brandon S.J. Davies, Michael M. Weinstein, Loren G. Fong, Anne P. Beigneux, Stephen G. Young, Thomas Olivecrona, Olle Hernell
Published 2010-06-01

Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24

by Sandy Y. Chang, Sarah E. Hudon-Miller, Shao H. Yang, Hea-Jin Jung, John M. Lee, Emily Farber, Thangaiah Subramanian, Douglas A. Andres, H.Peter Spielmann, Christine A. Hrycyna, Stephen G. Young, Loren G. Fong
Published 2012-06-01

Mutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding

by Christopher M. Allan, Cris J. Jung, Mikael Larsson, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Tiffany Ly P. Dang, Rachel S. Jung, Anne P. Beigneux, Pieter J. de Jong, Loren G. Fong, Stephen G. Young
Published 2017-07-01

Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells.

by Alex S Nord, Karen Vranizan, Whittemore Tingley, Alexander C Zambon, Kristina Hanspers, Loren G Fong, Yan Hu, Peter Bacchetti, Thomas E Ferrin, Patricia C Babbitt, Scott W Doniger, William C Skarnes, Stephen G Young, Bruce R Conklin
Published 2007-07-01

An LPL–specific monoclonal antibody, 88B8, that abolishes the binding of LPL to GPIHBP1[S]

by Christopher M. Allan, Mikael Larsson, Xuchen Hu, Cuiwen He, Rachel S. Jung, Alaleh Mapar, Constance Voss, Kazuya Miyashita, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, André Bensadoun, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Published 2016-10-01

An upstream enhancer regulates Gpihbp1 expression in a tissue-specific manner[S]

by Christopher M. Allan, Patrick J. Heizer, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Jazmin E. Morales, Eniko Sajti, Ty D. Troutman, Thomas L. Saunders, Darren A. Cusanovich, Anne P. Beigneux, Casey E. Romanoski, Loren G. Fong, Stephen G. Young
Published 2019-04-01

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]

by Patrick J. Heizer, Ye Yang, Yiping Tu, Paul H. Kim, Natalie Y. Chen, Yan Hu, Yuko Yoshinaga, Pieter J. de Jong, Laurent Vergnes, Jazmin E. Morales, Robert L. Li, Nicholas Jackson, Karen Reue, Stephen G. Young, Loren G. Fong
Published 2020-03-01

SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion

by Xiao-Wei Chen, He Wang, Kanika Bajaj, Pengcheng Zhang, Zhuo-Xian Meng, Danjun Ma, Yongsheng Bai, Hui-Hui Liu, Elizabeth Adams, Andrea Baines, Genggeng Yu, Maureen A Sartor, Bin Zhang, Zhengping Yi, Jiandie Lin, Stephen G Young, Randy Schekman, David Ginsburg
Published 2013-04-01

The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase

by John G. Luz, Anne P. Beigneux, DeeAnn K. Asamoto, Cuiwen He, Wenxin Song, Christopher M. Allan, Jazmin Morales, Yiping Tu, Adam Kwok, Thomas Cottle, Muthuraman Meiyappan, Loren G. Fong, Judy E. Kim, Michael Ploug, Stephen G. Young, Gabriel Birrane
Published 2020-10-01

Monoclonal antibodies that bind to the Ly6 domain of GPIHBP1 abolish the binding of LPL

by Xuchen Hu, Mark W. Sleeman, Kazuya Miyashita, MacRae F. Linton, Christopher M. Allan, Cuiwen He, Mikael Larsson, Yiping Tu, Norma P. Sandoval, Rachel S. Jung, Alaleh Mapar, Tetsuo Machida, Masami Murakami, Katsuyuki Nakajima, Michael Ploug, Loren G. Fong, Stephen G. Young, Anne P. Beigneux
Published 2017-01-01

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

by Xuchen Hu, Ken Matsumoto, Rachel S Jung, Thomas A Weston, Patrick J Heizer, Cuiwen He, Norma P Sandoval, Christopher M Allan, Yiping Tu, Harry V Vinters, Linda M Liau, Rochelle M Ellison, Jazmin E Morales, Lynn J Baufeld, Nicholas A Bayley, Liqun He, Christer Betsholtz, Anne P Beigneux, David A Nathanson, Holger Gerhardt, Stephen G Young, Loren G Fong, Haibo Jiang
Published 2019-06-01

Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium.

by Stuart Smith, Andrzej Witkowski, Ayesha Moghul, Yuko Yoshinaga, Michael Nefedov, Pieter de Jong, Dejiang Feng, Loren Fong, Yiping Tu, Yan Hu, Stephen G Young, Thomas Pham, Carling Cheung, Shana M Katzman, Martin D Brand, Casey L Quinlan, Marcel Fens, Frans Kuypers, Stephanie Misquitta, Stephen M Griffey, Son Tran, Afshin Gharib, Jens Knudsen, Hans Kristian Hannibal-Bach, Grace Wang, Sandra Larkin, Jennifer Thweatt, Saloni Pasta
Published 2012-01-01